{"doi":"10.1016/j.adro.2021.100857","title":"Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer","abstract":"Purpose: We sought to examine the prognostic value of fluorodeoxyglucose-positron emission tomography (PET) imaging during chemoradiation for unresectable non-small cell lung cancer for survival and hypothesized that tumor PET response is correlated with peripheral T-cell function. Methods and Materials: Forty-five patients with American Joint Committee on Cancer version 7 stage IIB-IIIB non-small cell lung cancer enrolled in a phase II trial and received platinum-doublet chemotherapy concurrent with 6 weeks of radiation (NCT02773238). Fluorodeoxyglucose-PET was performed before treatment start and after 24 Gy of radiation (week 3). PET response status was prospectively defined by multifactorial radiologic interpretation. PET responders received 60 Gy in 30 fractions, while nonresponders received concomitant boosts to 74 Gy in 30 fractions. Peripheral blood was drawn synchronously with PET imaging, from which germline DNA sequencing, T-cell receptor sequencing, and plasma cytokine analysis were performed. Results: = .031). Conclusions: Midchemoradiation PET imaging is prognostic for survival; PET response may be linked to tumor and peripheral T-cell biomarkers.","journal":"Advances in Radiation Oncology","year":2021,"id":204699,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420625,"name":"Daniel S. Hippe","orcid":"0000-0003-2427-4404","position":1,"is_corresponding":false},{"id":495831,"name":"Hannah Thomas","orcid":"0000-0002-1454-512X","position":2,"is_corresponding":false},{"id":787527,"name":"Balukrishna Sasidharan","orcid":null,"position":3,"is_corresponding":false},{"id":298616,"name":"Paul D. Lampe","orcid":"0000-0002-1399-2761","position":4,"is_corresponding":false},{"id":423767,"name":"Christina S. Baik","orcid":"0009-0007-0822-9060","position":5,"is_corresponding":false},{"id":347712,"name":"Keith D. Eaton","orcid":"0000-0001-5025-2001","position":6,"is_corresponding":false},{"id":581513,"name":"Sylvia Lee","orcid":"0009-0002-3059-4412","position":7,"is_corresponding":false},{"id":581514,"name":"Renato Martins","orcid":"0000-0003-2137-1145","position":8,"is_corresponding":false},{"id":423766,"name":"Rafael Santana-Dávila","orcid":"0000-0001-5051-1755","position":9,"is_corresponding":false},{"id":273859,"name":"Delphine L. Chen","orcid":"0000-0002-0150-5401","position":10,"is_corresponding":false},{"id":65783,"name":"Paul E. Kinahan","orcid":"0000-0001-6461-3306","position":11,"is_corresponding":false},{"id":420649,"name":"Robert S. Miyaoka","orcid":"0000-0001-8443-9843","position":12,"is_corresponding":false},{"id":421436,"name":"Hubert Vesselle","orcid":null,"position":13,"is_corresponding":false},{"id":232697,"name":"A. McGarry Houghton","orcid":"0000-0002-8970-3137","position":14,"is_corresponding":false},{"id":420650,"name":"Ramesh Rengan","orcid":"0000-0001-5379-536X","position":15,"is_corresponding":false},{"id":245118,"name":"Jing Zeng","orcid":"0000-0001-7388-8926","position":16,"is_corresponding":false},{"id":420651,"name":"Stephen R. Bowen","orcid":"0000-0001-7581-770X","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:51:26.121843Z","pmid":"35387421","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}