{"doi":"10.1016/j.adro.2021.100657","title":"Molecularly Targeted Radiation Therapy Using mTOR Inhibition for the Management of Malignant Perivascular Epithelioid Cell Tumor (PEComa): A Case Report and Review","abstract":"Malignant perivascular epithelioid cell tumor (PEComa) is a rare and aggressive mesenchymal tumor that most frequently develops within the gastrointestinal tract or pelvis and less commonly in the lung.1 Activation of the mammalian target of rapamycin (mTOR) signaling pathway, typically as a result of mutations or deletions in the tuberous sclerosis genes TSC1 or TSC2, has been implicated as a key molecular driver of PEComa.2 Limited retrospective studies examining the mTOR inhibitor sirolimus have found that it is generally well tolerated and usually associated with radiographic responses.","journal":"Advances in Radiation Oncology","year":2021,"id":209458,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":261751,"name":"Mohamed E. Abazeed","orcid":"0000-0002-6614-4440","position":1,"is_corresponding":false},{"id":797067,"name":"Amishi Bajaj","orcid":"0000-0002-6382-3667","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-18T23:52:05.171356Z","pmid":"34195492","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}