{"doi":"10.1016/j.adro.2020.01.009","title":"Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma in Patients With Child-Pugh B or C Cirrhosis","abstract":"PURPOSE: Our purpose was to report outcomes in patients with Child-Pugh B or C (CP B/C) hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Patients with HCC suitable for SBRT were prospectively enrolled in the study from 2012 to 2018. Outcomes in patients with CP B/C were analyzed. Cox proportional hazard models were used to compare survival outcomes between baseline CP score and post-SBRT CP score. RESULTS: Twenty-three patients with CP B/C with a total of 29 HCC tumors were treated with SBRT. Eighty-seven percent of patients were CP B8-C10. Median tumor size was 3.1 cm (range, 1-10 cm). Median dose delivered was 40 Gy in a median of 5 fractions. Eighteen of 23 patients (78.3%) had been previously treated with transarterial chemoembolization. Median follow-up was 14.5 months. Rates of 6- and 12-month local control were 100% and 92.3%, respectively. Six- and 12-month survival rates were 73.9% and 56.5%, respectively. Median survival was 14.5 months overall and 9.2, 22.5, 14.5, and 14.4 months for patients with CP B7, B8, B9, and C10, respectively. No patients exhibited symptoms of classic radiation-induced liver disease. However, 10 patients had CP score progression, with 4 patients (17%) having a ≥2-point increase in CP score by 6 months (or time of censor). There were 7 liver-related deaths, and based on independent review by a hepatologist, 1 of these deaths may have been attributable to SBRT-related liver injury. Fifteen of 23 patients were listed for liver transplant (LT) at the time of SBRT and 9 went on to receive LT with a pathologic complete response rate of 63.6%. Median survival, excluding patients who received LT, was 7.3 months. CONCLUSIONS: SBRT is a reasonable treatment option for carefully selected patients with CP B7-C10. In our small cohort, there was no detectable difference between local control or overall survival and baseline CP score.","journal":"Advances in Radiation Oncology","year":2020,"id":68269,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361708,"name":"Yunsheng Ma","orcid":"0000-0003-2317-3716","position":1,"is_corresponding":false},{"id":362949,"name":"Isabel Zacharias","orcid":null,"position":2,"is_corresponding":false},{"id":361709,"name":"Adel Bozorgzadeh","orcid":"0000-0002-0790-9562","position":3,"is_corresponding":false},{"id":361710,"name":"Sean R. Wilson","orcid":"0000-0002-7672-0421","position":4,"is_corresponding":false},{"id":362950,"name":"Kim Foley","orcid":null,"position":5,"is_corresponding":false},{"id":361711,"name":"Paul Rava","orcid":"0000-0001-7291-8863","position":6,"is_corresponding":false},{"id":361712,"name":"Mark Masciocchi","orcid":"0000-0003-2960-357X","position":7,"is_corresponding":false},{"id":361713,"name":"Linda Ding","orcid":"0000-0002-6209-6998","position":8,"is_corresponding":false},{"id":271709,"name":"Jacob R. Bledsoe","orcid":"0000-0002-2387-5462","position":9,"is_corresponding":false},{"id":361714,"name":"Thomas J. FitzGerald","orcid":"0000-0002-6256-0615","position":10,"is_corresponding":false},{"id":362951,"name":"Shirin Sioshansi","orcid":null,"position":11,"is_corresponding":false},{"id":361707,"name":"Peter Lee","orcid":"0000-0002-7897-3721","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T21:40:52.680475Z","pmid":"33083650","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}