{"doi":"10.1016/j.addr.2021.05.008","title":"Tumor-on-chip modeling of organ-specific cancer and metastasis","abstract":"Every year, cancer claims millions of lives around the globe. Unfortunately, model systems that accurately mimic human oncology - a requirement for the development of more effective therapies for these patients - remain elusive. Tumor development is an organ-specific process that involves modification of existing tissue features, recruitment of other cell types, and eventual metastasis to distant organs. Recently, tissue engineered microfluidic devices have emerged as a powerful in vitro tool to model human physiology and pathology with organ-specificity. These organ-on-chip platforms consist of cells cultured in 3D hydrogels and offer precise control over geometry, biological components, and physiochemical properties. Here, we review progress towards organ-specific microfluidic models of the primary and metastatic tumor microenvironments. Despite the field's infancy, these tumor-on-chip models have enabled discoveries about cancer immunobiology and response to therapy. Future work should focus on the development of autologous or multi-organ systems and inclusion of the immune system.","journal":"Advanced Drug Delivery Reviews","year":2021,"id":148510,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":125,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311778,"name":"Venktesh S. Shirure","orcid":"0000-0002-4430-2612","position":1,"is_corresponding":false},{"id":311777,"name":"Ye Bi","orcid":"0000-0002-3939-791X","position":2,"is_corresponding":false},{"id":266773,"name":"S. Peter Goedegebuure","orcid":"0000-0001-7084-3378","position":3,"is_corresponding":false},{"id":385352,"name":"Sepideh Gholami","orcid":"0000-0001-9294-1710","position":4,"is_corresponding":false},{"id":281522,"name":"Christopher C.W. Hughes","orcid":"0000-0002-3223-830X","position":5,"is_corresponding":false},{"id":31720,"name":"Ryan C. Fields","orcid":"0000-0001-6176-8943","position":6,"is_corresponding":false},{"id":311780,"name":"Steven C. George","orcid":"0000-0003-2263-1914","position":7,"is_corresponding":false},{"id":632068,"name":"Nuala Del Piccolo","orcid":"0000-0002-5104-7322","position":0,"is_corresponding":true}],"reference_count":265,"raw_metadata":null,"created_at":"2026-07-18T23:42:46.224799Z","pmid":"34015419","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}