{"doi":"10.1016/j.actatropica.2017.06.024","title":"Protection against mosquito vectors  Aedes aegypti, Anopheles stephensi  and  Culex quinquefasciatus  using a novel insect repellent, ethyl anthranilate","abstract":null,"journal":"Acta Tropica","year":2017,"id":681679,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1781025,"name":"Kamaruz Zaman","orcid":null,"position":1,"is_corresponding":false},{"id":1781026,"name":"Varun Tyagi","orcid":null,"position":2,"is_corresponding":false},{"id":1781027,"name":"Sanjukta Duarah","orcid":null,"position":3,"is_corresponding":false},{"id":1781029,"name":"Sunil Dhiman","orcid":null,"position":4,"is_corresponding":false},{"id":1781030,"name":"Pronobesh Chattopadhyay","orcid":null,"position":5,"is_corresponding":false},{"id":1781024,"name":"Johirul Islam","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Protection against mosquito vectors  Aedes aegypti, Anopheles stephensi  and  Culex quinquefasciatus  using a novel insect repellent, ethyl anthranilate","abstract":"Growing concern on the application of synthetic mosquito repellents in the recent years has instigated the identification and development of better alternatives to control different mosquito-borne diseases. In view of above, present investigation evaluates the repellent activity of ethyl anthranilate (EA), a non-toxic, FDA approved volatile food additive against three known mosquito vectors namely, Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus under laboratory conditions following standard protocols. Three concentration levels (2%, 5% and 10% w/v) of EA were tested against all the three selected mosquito species employing K & D module and arm-in-cage method to determine the effective dose (ED<sub>50</sub>) and complete protection time (CPT), respectively. The repellent activity of EA was further investigated by modified arm-in-cage method to determine the protection over extended spatial ranges against all mosquito species. All behavioural situations were compared with the well-documented repellent N,N-diethylphenyl acetamide (DEPA) as a positive control. The findings demonstrated that EA exhibited significant repellent activity against all the three mosquitoes species. The ED<sub>50</sub> values of EA, against Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus were found to be 0.96%, 5.4% and 3.6% w/v, respectively. At the concentration of 10% w/v, it provided CPTs of 60, 60 and 30min, respectively, against Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus mosquitoes. Again in spatial repellency evaluation, EA was found to be extremely effective in repelling all the three tested species of mosquitoes. Ethyl anthranilate provided comparable results to standard repellent DEPA during the study. Results have concluded that the currently evaluated chemical, EA has potential repellent activity against some well established mosquito vectors. The study emphasizes that repellent activity of EA could be exploited for developing effective, eco-friendly, acceptable and safer alternative to the existing harmful repellents for personal protection against different hematophagous mosquito species.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28666890","pmcid":null,"openalex_id":"https://openalex.org/W2733561874","authors":[],"funders":[],"total_grants":0,"fwci":7.1606,"citation_percentile":0.96120555,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2021,"count":9},{"year":2022,"count":6},{"year":2023,"count":5},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0001706X17301511?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0001706X17301511?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.actatropica.2017.06.024","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28666890","host_type":"repository"}],"fields_of_study":["Insect Pest Control Strategies","Mosquito-borne diseases and control","Insect and Pesticide Research","Aedes","Animals","Anopheles","Culex","Insect Repellents","Mosquito Vectors","Nerve Tissue Proteins","Xenopus Proteins","ortho-Aminobenzoates"],"mesh_terms":["Mosquito Vectors","Aedes","Animals","Anopheles","Culex","Insect Repellents","Nerve Tissue Proteins","Xenopus Proteins","ortho-Aminobenzoates"],"keywords":["Anopheles stephensi","Culex quinquefasciatus","Aedes aegypti","Mosquito control","Biology","Aedes","Toxicology","Anopheles","Insect repellent","Culex","DEET","Veterinary medicine","Larva","Malaria","Botany","Ecology","Medicine","Immunology","Dengue","Arbovirus","Mosquito Repellent","Zika Fever","Ethyl Anthranilate"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14299291.v1","title":"Additional file 1 of Mosquito‐repellent controlled‐release formulations for fighting infectious diseases","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14299291","title":"Additional file 1 of Mosquito‐repellent controlled‐release formulations for fighting infectious diseases","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T18:24:40.609785Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}