{"doi":"10.1016/j.aca.2022.340253","title":"A novel Apt-SERS platform for the determination of cardiac troponin I based on coral-like silver-modified magnetic substrate and BCA method","abstract":null,"journal":"Analytica Chimica Acta","year":2022,"id":613343,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":914289,"name":"Lijun Li","orcid":"0000-0002-2755-4068","position":1,"is_corresponding":false},{"id":796395,"name":"Jun Feng","orcid":"0000-0003-4132-7627","position":2,"is_corresponding":false},{"id":367401,"name":"Yan Zhang","orcid":"0000-0002-6041-4454","position":3,"is_corresponding":false},{"id":1580083,"name":"Heyuanxi Guo","orcid":null,"position":4,"is_corresponding":false},{"id":595858,"name":"Xin Lin","orcid":"0000-0001-6913-4654","position":5,"is_corresponding":false},{"id":583253,"name":"Rui Li","orcid":"0000-0003-1448-6489","position":6,"is_corresponding":false},{"id":1580082,"name":"Chubing Lin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A novel Apt-SERS platform for the determination of cardiac troponin I based on coral-like silver-modified magnetic substrate and BCA method","abstract":"As a kind of acute cardiovascular disease, acute myocardial infarction (AMI) endangers human's life and fitness seriously. The detection of cardiac troponin I (cTnI), a biomarker of AMI, is the key to early medical prognosis and treatment. Surface-enhanced Raman spectroscopy is viewed to be an effective approach for detection of low-concentration substances, and aptamers are regarded to be effective fragments to recognize proteins specifically. In this work, a magnetic nanoparticle substrate coated with coral-like nano-silver was prepared, and the aptamer-modified substrate Fe3O4@PEI/Ag NC-Apt was used as magnetic capture probe. Combined with BCA method and SERS detection technology, an Apt-SERS platform was successfully constructed and used for high sensitivity quantitative detection of protein. Taking cTnI as the target, the detection range of the proposed Apt-SERS platform was 0.001-100 ng mL-1, and the estimated detection of limit (LOD) was 0.23 pg mL-1. The recovery and relative standard deviations (RSD) of spiked experiment in human serum samples were 92-106% and 3.8-10.1%, respectively. The platform combining BCA method and SERS provides a high sensitivity and good reproducibility method for cTnI detection, which offers a new method for the specific detection and analysis of proteins.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36038245","pmcid":null,"openalex_id":"https://openalex.org/W4291295733","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81860633","title":null},{"funder_name":"Natural Science Foundation of Guangxi Province","grant_id":"2019GXNSFDA245025","title":null}],"total_grants":2,"fwci":1.5021,"citation_percentile":0.80527556,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":9},{"year":2026,"count":7}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0003267022008248?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0003267022008248?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.aca.2022.340253","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36038245","host_type":"repository"}],"fields_of_study":["Biosensors and Analytical Detection","Characterization and Applications of Magnetic Nanoparticles","Gold and Silver Nanoparticles Synthesis and Applications","Animals","Anthozoa","Gold","Humans","Limit of Detection","Magnetic Phenomena","Metal Nanoparticles","Myocardial Infarction","Proteins","Reproducibility of Results","Spectrum Analysis, Raman","Troponin I"],"mesh_terms":["Animals","Gold","Humans","Myocardial Infarction","Proteins","Spectrum Analysis, Raman","Reproducibility of Results","Troponin I","Anthozoa","Metal Nanoparticles","Limit of Detection","Magnetic Phenomena"],"keywords":["Chemistry","Substrate (aquarium)","Coral","Nanotechnology","Analytical Chemistry (journal)","Environmental chemistry","Oceanography","BCA method","Cardiac troponin I","Coral-like nano-sliver","Surface-enhanced Raman scattering"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T07:44:11.561760Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}