{"doi":"10.1016/j.abb.2004.08.030","title":"Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR","abstract":null,"journal":"Archives of Biochemistry and Biophysics","year":2005,"id":589645,"datarank":7.628077243051232,"base_score":5.14166355650266,"endowment":5.14166355650266,"self_citation_contribution":0.7712495334753992,"citation_network_contribution":6.856827709575833,"self_endowment_contribution":0.7712495334753992,"citer_contribution":6.856827709575833,"corpus_percentile":null,"corpus_rank":null,"citation_count":170,"citer_count":168,"citers_with_citation_signal":148,"citers_with_endowment":148,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1508604,"name":"Urs A. Meyer","orcid":null,"position":1,"is_corresponding":false},{"id":1508603,"name":"Christoph Handschin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR","abstract":"Cloning and characterization of the orphan nuclear receptors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) led to major breakthroughs in studying drug-mediated transcriptional induction of drug-metabolizing cytochromes P450 (CYPs). More recently, additional roles for CAR and PXR have been discovered. As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4). In this review, functional interactions between these nuclear receptors as well as the consequences on physiology and pathophysiology of the liver are discussed.","is_dataset_classified":null,"base_score":5.14166355650266,"endowment":5.14166355650266,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15581595","pmcid":null,"openalex_id":"https://openalex.org/W2141628779","authors":[],"funders":[],"total_grants":0,"fwci":8.042,"citation_percentile":0.98297386,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":8},{"year":2014,"count":8},{"year":2015,"count":5},{"year":2016,"count":6},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0003986104004953?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0003986104004953?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.abb.2004.08.030","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15581595","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Pharmacogenetics and Drug Metabolism","Cholesterol and Lipid Metabolism","Animals","Bile Acids and Salts","Bilirubin","Cell Nucleus","Cholesterol","Cloning, Molecular","Constitutive Androstane Receptor","Cytochrome P-450 Enzyme System","DNA-Binding Proteins","Humans","Lipid Metabolism","Liver","Liver X Receptors","Models, Biological","Orphan Nuclear Receptors","Phylogeny","Pregnane X Receptor","Receptors, Cytoplasmic and Nuclear","Receptors, Steroid","Species Specificity","Transcription Factors","Xenobiotics","Receptor, Farnesoid X-Activated"],"mesh_terms":["Liver X Receptors","Pregnane X Receptor","Constitutive Androstane Receptor","Receptor, Farnesoid X-Activated","Animals","Bile Acids and Salts","Bilirubin","Cell Nucleus","Cholesterol","Cloning, Molecular","Cytochrome P-450 Enzyme System","DNA-Binding Proteins","Humans","Liver","Models, Biological","Phylogeny","Receptors, Steroid","Species Specificity","Transcription Factors","Xenobiotics","Receptors, Cytoplasmic and Nuclear","Lipid Metabolism","Orphan Nuclear Receptors"],"keywords":["Pregnane X receptor","Nuclear receptor","Constitutive androstane receptor","Farnesoid X receptor","Liver X receptor","Receptor","Bile acid","Liver receptor homolog-1","Liver X receptor alpha","Retinoid X receptor","Biology","Cholesterol 7 alpha-hydroxylase","Small heterodimer partner","Cell biology","Biochemistry","Chemistry","Transcription factor","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T01:35:04.374739Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}