{"doi":"10.1016/bs.mcb.2018.03.002","title":"Quantitative methods to measure aneuploidy and chromosomal instability","abstract":null,"journal":"Methods in Cell Biology","year":2018,"id":656788,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399826,"name":"Duane A. Compton","orcid":"0000-0002-4445-9118","position":1,"is_corresponding":false},{"id":1714431,"name":"Kristina M. Godek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Quantitative methods to measure aneuploidy and chromosomal instability","abstract":"Cell viability requires accurate chromosome segregation during meiosis and mitosis so that the daughter cells produced have the correct chromosome complement. In contrast, chromosome segregation errors lead to aneuploidy, a state of abnormal chromosome numbers. Furthermore, a persistently high rate of chromosome segregation errors causes the related phenomenon of whole chromosomal instability (w-CIN). Aneuploidy and w-CIN are common characteristics of several human conditions and diseases including birth defects and cancers. Thus, methods to measure aneuploidy and w-CIN have important research applications in many areas of cell biology. In this chapter, we describe methods to measure chromosome missegregation rates and aneuploid cell survival with a focus on cells grown in culture; however, we also highlight methods that are amenable to primary tissue samples. Together, these methods provide a comprehensive approach to determining the frequency of aneuploidy and w-CIN in cells.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29804667","pmcid":"PMC6475901","openalex_id":"https://openalex.org/W2800567484","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM051542","title":null}],"total_grants":1,"fwci":4.518,"citation_percentile":0.93886097,"influential_citations":0,"citation_trend":[{"year":2020,"count":7},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":6},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0091679X18300025?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0091679X18300025?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/bs.mcb.2018.03.002","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29804667","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6475901","host_type":"repository"}],"fields_of_study":["Microtubule and mitosis dynamics","Genomic variations and chromosomal abnormalities","Genomics and Chromatin Dynamics","Aneuploidy","Biological Assay","Cell Line, Tumor","Cell Survival","Chromosomal Instability","Chromosome Segregation","Chromosomes, Human","Cytological Techniques","Fluorescent Antibody Technique","Humans","In Situ Hybridization, Fluorescence","Mitosis"],"mesh_terms":["Aneuploidy","Biological Assay","Cell Survival","Chromosomes, Human","Cytological Techniques","Fluorescent Antibody Technique","Humans","Mitosis","In Situ Hybridization, Fluorescence","Chromosome Segregation","Chromosomal Instability","Cell Line, Tumor"],"keywords":["Aneuploidy","Biology","Chromosome instability","Chromosome segregation","Chromosome","Mitosis","Meiosis","Genetics","Cell biology","Gene","Fluorescent In Situ Hybridization (Fish)","Lagging Chromosomes","Chromosome Missegregation","Chromosomal Instability (Cin)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12269879.v1","title":"Additional file 1 of Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12269879","title":"Additional file 1 of Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T22:16:15.558520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}