{"doi":"10.1016/bs.apcsb.2016.10.002","title":"The Functional Stability of FOXP3 and RORγt in Treg and Th17 and Their Therapeutic Applications","abstract":null,"journal":null,"year":null,"id":640194,"datarank":0.635115975689589,"base_score":4.23410650459726,"endowment":4.23410650459726,"self_citation_contribution":0.635115975689589,"citation_network_contribution":0.0,"self_endowment_contribution":0.635115975689589,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Functional Stability of FOXP3 and RORγt in Treg and Th17 and Their Therapeutic Applications","abstract":"The balance of CD4<sup>+</sup>CD25<sup>+</sup>FOXP3<sup>+</sup> regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORγt or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.","is_dataset_classified":null,"base_score":4.23410650459726,"endowment":4.23410650459726,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28215223","pmcid":null,"openalex_id":"https://openalex.org/W2563505151","authors":[],"funders":[],"total_grants":0,"fwci":5.6628,"citation_percentile":0.96219422,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":5},{"year":2020,"count":12},{"year":2021,"count":11},{"year":2022,"count":15},{"year":2023,"count":6},{"year":2024,"count":6},{"year":2025,"count":7},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1876162316300554?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1876162316300554?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/bs.apcsb.2016.10.002","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28215223","host_type":"repository"}],"fields_of_study":["Immune Cell Function and Interaction","Dermatology and Skin Diseases","IL-33, ST2, and ILC Pathways","Animals","Forkhead Transcription Factors","Humans","Nuclear Receptor Subfamily 1, Group F, Member 3","Protein Stability","T-Lymphocytes, Regulatory","Th17 Cells"],"mesh_terms":["Animals","Humans","T-Lymphocytes, Regulatory","Forkhead Transcription Factors","Protein Stability","Nuclear Receptor Subfamily 1, Group F, Member 3","Th17 Cells"],"keywords":["FOXP3","Treg cell","Effector","RAR-related orphan receptor gamma","Homeostasis","Immune system","Immunology","IL-2 receptor","Biology","Cell biology","T cell","Disease","Plasticity","Th17","Tregs","Rorγt"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T07:45:07.918640Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}