{"doi":"10.1016/0732-8893(92)90045-u","title":"In vivo activity of the combination of daptomycin and fosfomycin compared with daptomycin alone against a strain of Enterococcus faecalis with high-level gentamicin resistance in the rat endocarditis model","abstract":null,"journal":"Diagnostic Microbiology and Infectious Disease","year":1992,"id":681490,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1780533,"name":"Claudie Thauvin Eliopoulos","orcid":null,"position":1,"is_corresponding":false},{"id":1780535,"name":"Joseph D.C. Yao","orcid":null,"position":2,"is_corresponding":false},{"id":1780537,"name":"George M. Eliopoulos","orcid":null,"position":3,"is_corresponding":false},{"id":1780542,"name":"Robert C. Moellering","orcid":null,"position":4,"is_corresponding":false},{"id":54063,"name":"Louis B. Rice","orcid":"0000-0002-0265-7124","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"In vivo activity of the combination of daptomycin and fosfomycin compared with daptomycin alone against a strain of Enterococcus faecalis with high-level gentamicin resistance in the rat endocarditis model","abstract":"The in vivo activity of the combination of daptomycin and fosfomycin against a beta-lactamase-producing, highly gentamicin-resistant strain of Enterococcus faecalis in a relapse model of rat endocarditis was studied. Minimum inhibitory concentrations (MICs) (micrograms per milliliter) for these agents against this strain were 4 (daptomycin) and 16 (fosfomycin). Time-kill studies demonstrated synergistic bactericidal activity when daptomycin (0.5 micrograms/ml) and fosfomycin (32 micrograms/ml) were combined. There was no significant difference between the number of valves sterilized by daptomycin alone [six (35%) of 17 valves sterilized] and daptomycin+fosfomycin [ten (59%) of 17 valves sterilized] p = 0.3. These results suggest that the in vitro bactericidal synergism demonstrable between these two agents against strains of enterococci will not necessarily translate into greater therapeutic efficacy in clinical infections.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1315234","pmcid":null,"openalex_id":"https://openalex.org/W1997876189","authors":[],"funders":[],"total_grants":0,"fwci":0.2779,"citation_percentile":0.54291262,"influential_citations":2,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":3},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1016/0732-8893(92)90045-u","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1315234","host_type":"repository"}],"fields_of_study":["Antimicrobial Resistance in Staphylococcus","Antibiotic Resistance in Bacteria","Infective Endocarditis Diagnosis and Management","Biology","Medicine","Animals","Daptomycin","Disease Models, Animal","Drug Synergism","Drug Therapy, Combination","Endocarditis, Bacterial","Enterococcus faecalis","Fosfomycin","Gram-Positive Bacterial Infections","Male","Microbial Sensitivity Tests","Peptides","Rats","Rats, Inbred Strains"],"mesh_terms":["Animals","Disease Models, Animal","Drug Synergism","Drug Therapy, Combination","Endocarditis, Bacterial","Fosfomycin","Male","Microbial Sensitivity Tests","Peptides","Rats, Inbred Strains","Enterococcus faecalis","Gram-Positive Bacterial Infections","Daptomycin","Rats"],"keywords":["Daptomycin","Fosfomycin","Enterococcus faecalis","Microbiology","Gentamicin","Endocarditis","In vivo","Antibiotics","Enterococcus","Minimum inhibitory concentration","Strain (injury)","Antibacterial agent","Pharmacology","Medicine","Biology","Bacteria","Vancomycin","Staphylococcus aureus","Surgery","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T17:57:46.678647Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}