{"doi":"10.1016/0005-2736(85)90504-8","title":"Two modes of inhibition of the Ca2+ pump in red cells by Ca2+","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Biomembranes","year":1985,"id":601829,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1543228,"name":"Patricio J. Garrahan","orcid":null,"position":1,"is_corresponding":false},{"id":1543231,"name":"Alcides F. Rega","orcid":null,"position":2,"is_corresponding":false},{"id":1543226,"name":"Ricardo B. Kratje","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Two modes of inhibition of the Ca2+ pump in red cells by Ca2+","abstract":"Two different and independent modes of inhibition of the Ca2+ pump by Ca2+ can be detected measuring active Ca2+ extrusion from resealed ghosts of human red cells: one requires extracellular and the other requires intracellular Ca2+. Ki for inhibition by extracellular Ca2+ is about 10 mM. Extracellular Mg2+ replaces Ca2+ in inhibiting Ca2+ transport but with an apparent affinity for inhibition about 3-times less than that for Ca2+. Inhibition by external Ca2+ is not affected by Na+ or K+ at both surfaces of the cell membrane, external EGTA, internal Ca2+ or ATP. The apparent affinity for external Ca2+ progressively raises as pH increases. The effects of extracellular Ca2+ and Mg2+ are consistent with the idea that for Ca2+ pumping to proceed, external sites in the pump must be protonated and not occupied by extracellular Ca2+ or Mg2+. Inhibition by intracellular Ca2+ takes place with a Ki of about 1 mM and is independent of external Ca2+. The inhibitory effects of intracellular Ca2+ can be accounted for if Ca2+ and CaATP were competitive inhibitors of the activation of the pump by Mg2+ and MgATP, respectively.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3159426","pmcid":null,"openalex_id":"https://openalex.org/W2014034588","authors":[],"funders":[],"total_grants":0,"fwci":1.1407,"citation_percentile":0.77257666,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:0005273685905048?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:0005273685905048?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/0005-2736(85)90504-8","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3159426","host_type":"repository"}],"fields_of_study":["Ion channel regulation and function","Pancreatic function and diabetes","Neuroscience and Neuropharmacology Research"],"mesh_terms":["Calcium-Transporting ATPases","Adenosine Triphosphate","Calcium","Egtazic Acid","Erythrocytes","Extracellular Space","Humans","Hydrogen-Ion Concentration","Intracellular Fluid","Kinetics","Magnesium","Mathematics","Potassium","Sodium"],"keywords":["Extracellular","Intracellular","EGTA","Biophysics","Chemistry","Calcium","Biochemistry","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T17:34:22.019684Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}