{"doi":"10.1007/s43630-023-00467-5","title":"Evaluation of photobiomodulation therapy (117 and 90s) on pain, regeneration, and epigenetic factors (HDAC 2, DNMT3a) expression following spinal cord injury in a rat model","abstract":null,"journal":"Photochemical &amp; Photobiological Sciences","year":2023,"id":614539,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":672153,"name":"Zahra Behroozi","orcid":"0000-0002-8375-7441","position":1,"is_corresponding":false},{"id":1583648,"name":"Keihan Kookli","orcid":null,"position":2,"is_corresponding":false},{"id":1583649,"name":"Alireza Ghadaksaz","orcid":null,"position":3,"is_corresponding":false},{"id":1583650,"name":"Seyedalireza Moghaddas Fazeli","orcid":null,"position":4,"is_corresponding":false},{"id":1583651,"name":"Ali Moshiri","orcid":null,"position":5,"is_corresponding":false},{"id":672156,"name":"Fatemeh Ramezani","orcid":"0000-0002-8545-3521","position":6,"is_corresponding":false},{"id":1583652,"name":"Molood Gooniband Shooshtari","orcid":null,"position":7,"is_corresponding":false},{"id":672152,"name":"Atousa Janzadeh","orcid":"0000-0003-2716-4526","position":8,"is_corresponding":false},{"id":1583647,"name":"Ali Motamed Nezhad","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Evaluation of photobiomodulation therapy (117 and 90s) on pain, regeneration, and epigenetic factors (HDAC 2, DNMT3a) expression following spinal cord injury in a rat model","abstract":"<h4>Background</h4>Photobiomodulation therapy (PBMT), due to its anti-inflammatory, analgesic effects, and most importantly as a non-invasive procedure, has currently gained a special setting in pain relief and the treatment of Spinal cord injuries (SCI). However, the mechanism of action of the PBM is not yet completely understood.<h4>Methods</h4>In this study, SCI is induced by an aneurysm clip, and PBM therapy was applied by a continuous-wave (CW) laser with a wavelength of 660 nm. Adult male rats were divided into four groups: Control, SCI, SCI + PBMT 90s, and SCI + PBMT 117s. After 7 weeks, hyperalgesia, allodynia, and functional recovery were assessed. Fibroblasts infiltrating the spinal cord were counted after H&E staining. The expression of epigenetic factors (HDAC2, DNMT3a), protein relevant for pain (GAD65), and astrocytes marker (GFAP) after 4 weeks of daily PBMT (90 and 117s) was probed by western blotting.<h4>Results</h4>Both PBMTs (90 and 117s) significantly improved the pain and ability to move and fibroblast invasion was reduced. SCI + PBMT 90s, increased GAD65, HDAC2, and DNMT3a expression. However, PBMT 117s decreased GFAP, HDAC2, and DNMT3a.<h4>Conclusion</h4>PBMT 90 and 117s improved the pain, and functional recovery equally. The regulation of epigenetic mechanisms appears to be a significant effect of PBMT117s, which emphasizes on impact of radiation duration and accumulative energy.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37787959","pmcid":null,"openalex_id":"https://openalex.org/W4387296445","authors":[],"funders":[{"funder_name":"Iran University of Medical Sciences","grant_id":"98-4-68-16528","title":null}],"total_grants":1,"fwci":2.1723,"citation_percentile":0.87999475,"influential_citations":0,"citation_trend":[{"year":2024,"count":7},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s43630-023-00467-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s43630-023-00467-5/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s43630-023-00467-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37787959","host_type":"repository"}],"fields_of_study":["Laser Applications in Dentistry and Medicine","Dermatologic Treatments and Research","Periodontal Regeneration and Treatments","Rats","Male","Animals","Low-Level Light Therapy","Spinal Cord Injuries","Hyperalgesia","Anti-Inflammatory Agents, Non-Steroidal","Neuralgia","Epigenesis, Genetic"],"mesh_terms":["Animals","Anti-Inflammatory Agents, Non-Steroidal","Hyperalgesia","Male","Neuralgia","Spinal Cord Injuries","Low-Level Light Therapy","Epigenesis, Genetic","Rats"],"keywords":["Medicine","Spinal cord","Anesthesia","Spinal cord injury","Trichostatin A","Histone deacetylase 2","Pharmacology","Histone deacetylase","Histone","Chemistry","Neuropathic pain","Photobiomodulation Therapy","Dna Methyltransferase 3 Alpha"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T14:11:31.056466Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}