{"doi":"10.1007/s43440-023-00461-9","title":"Drug repositioning: diacerein as a new therapeutic approach in a mice model of sciatic nerve injury","abstract":null,"journal":"Pharmacological Reports","year":2023,"id":661843,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1727815,"name":"Tassiane Emanuelle Servare Andrade","orcid":null,"position":1,"is_corresponding":false},{"id":1727817,"name":"Scheila Iria Kraus","orcid":null,"position":2,"is_corresponding":false},{"id":1727818,"name":"Larissa May Beppler","orcid":null,"position":3,"is_corresponding":false},{"id":1727819,"name":"Gustavo dos Santos Catarina de Jesus","orcid":null,"position":4,"is_corresponding":false},{"id":1727820,"name":"Jeane Bachi Ferreira","orcid":null,"position":5,"is_corresponding":false},{"id":387877,"name":"Morgana Duarte da Silva","orcid":"0000-0002-2487-236X","position":6,"is_corresponding":false},{"id":1727813,"name":"Jhenifer Karvat","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Drug repositioning: diacerein as a new therapeutic approach in a mice model of sciatic nerve injury","abstract":"<h4>Background</h4>Peripheral nerve injuries negatively impact the quality of life of patients, with no effective treatment available that accelerates sensorimotor recovery and promotes functional improvement and pain relief. The aim of this study was to evaluate the effects of diacerein (DIA) in an experimental mice model of sciatic nerve crush.<h4>Method</h4>In this study, male Swiss mice were used, randomly separated into six groups as follows: FO (false-operated + vehicle); FO + DIA (false-operated + diacerein 30 mg/kg); SNI (sciatic nerve injury + vehicle); SNI + DIA in doses of 3, 10 and 30 mg/kg (sciatic nerve injury + treatment with diacerein in doses of 3-30 mg/kg). DIA or vehicle was administered 24 h after the surgical procedure, intragastrically, twice a day. The lesion of the right sciatic nerve was generated by crush.<h4>Results</h4>We found that the treatment of animals with DIA accelerated sensorimotor recovery of the animal. In addition, animals in the sciatic nerve injury + vehicle (SNI) group showed hopelessness, anhedonia, and lack of well-being, which were significantly inhibited by DIA treatment. The SNI group showed a reduction in the diameters of nerve fibers, axons, and myelin sheaths, while DIA treatment recovered all these parameters. In addition, the treatment of animals with DIA prevented an increase the levels of interleukin (IL)-1β and a reduction in the levels of the brain-derived growth factor (BDNF).<h4>Conclusions</h4>Treatment with DIA reduces hypersensitivity and depression like behaviors in animals. Furthermore, DIA promotes functional recovery and regulates IL-1β and BDNF concentrations.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36809646","pmcid":null,"openalex_id":"https://openalex.org/W4321435418","authors":[],"funders":[],"total_grants":0,"fwci":0.3352,"citation_percentile":0.47109248,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s43440-023-00461-9.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s43440-023-00461-9/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s43440-023-00461-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36809646","host_type":"repository"}],"fields_of_study":["Nerve injury and regeneration","Pain Mechanisms and Treatments","Neurogenesis and neuroplasticity mechanisms","Mice","Male","Animals","Brain-Derived Neurotrophic Factor","Peripheral Nerve Injuries","Drug Repositioning","Quality of Life","Sciatic Neuropathy","Sciatic Nerve","Disease Models, Animal"],"mesh_terms":["Animals","Disease Models, Animal","Male","Quality of Life","Sciatic Nerve","Brain-Derived Neurotrophic Factor","Sciatic Neuropathy","Mice","Drug Repositioning","Peripheral Nerve Injuries"],"keywords":["Sciatic nerve","SNi","Medicine","Nerve injury","Sciatic nerve injury","Anesthesia","Crush injury","Lesion","Peripheral nerve injury","Neuropathic pain","Surgery","Chemistry","Hypersensitivity","peripheral nerve regeneration","Diacerein","Drug Repositioning"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T11:46:15.764035Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}