{"doi":"10.1007/s41105-025-00581-0","title":"Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice","abstract":null,"journal":"Sleep and Biological Rhythms","year":2025,"id":631271,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1635899,"name":"Linshan An","orcid":null,"position":1,"is_corresponding":false},{"id":331410,"name":"Rui Xie","orcid":"0000-0001-9769-8131","position":2,"is_corresponding":false},{"id":1635900,"name":"Jiahong Cai","orcid":null,"position":3,"is_corresponding":false},{"id":385613,"name":"Dong Li","orcid":"0000-0002-5084-3781","position":4,"is_corresponding":false},{"id":932599,"name":"Xiaorong Chen","orcid":"0000-0003-0185-0624","position":5,"is_corresponding":false},{"id":1243332,"name":"Wenjing Guo","orcid":"0000-0001-8271-9374","position":6,"is_corresponding":false},{"id":1635901,"name":"Yinran Lin","orcid":null,"position":7,"is_corresponding":false},{"id":1635902,"name":"Chunjing Zhu","orcid":null,"position":8,"is_corresponding":false},{"id":1635903,"name":"Yongli Chang","orcid":null,"position":9,"is_corresponding":false},{"id":626089,"name":"Kunbo Wang","orcid":"0000-0002-7850-5928","position":10,"is_corresponding":false},{"id":1635904,"name":"Weina Han","orcid":null,"position":11,"is_corresponding":false},{"id":1635905,"name":"Lingna Han","orcid":"0000-0002-8759-8767","position":12,"is_corresponding":false},{"id":202633,"name":"Li Yuan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice","abstract":"Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function and emotional disturbances. The amygdala is an important connectivity structure in the brain and is responsible for emotional responses. 5-HT is involved in various neurodevelopmental processes in the brain. In this study, correlation study of 5-HT in brain with cognitive function and anxious-like behavior was investigated in APP/PS1 transgene mice. Multiple behavioral tests were performed to examine the cognitive function and anxiety behavior of AD mice. In vivo hippocampus long-term potentiation (LTP) was recorded to reflect synaptic plasticity. 5-HT levels in hippocampus and amygdala were determined. Further, we explored the correlation between 5-HT levels in hippocampus and amygdala and long-term cognitive behaviors and anxiety behaviors in the AD mice using linear regression analysis. Our results demonstrated that there was close linear correlation between 5-HT level in brain and spatial cognition and anxiety behavior of APP/PS1 transgene mice. 5-HT influences spatial learning and memory by regulating the synaptic plasticity in hippocampus of APP/PS1 transgenic mice. These results indicate that 5-HT might be potentially beneficial in the treatment of AD.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40538392","pmcid":"PMC12173973","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81600951","title":null},{"funder_name":"Natural Science Foundation of Shanxi Province","grant_id":"20210302124324","title":null},{"funder_name":"Natural Science Foundation of Shanxi Province","grant_id":"202203021221302","title":null},{"funder_name":"Natural Science Foundation of Shanxi Province","grant_id":"20210302124194","title":null},{"funder_name":"Scientific and technological Innovation Project of Colleges and Universities in Shanxi Province","grant_id":"2020L0386","title":null},{"funder_name":"Health Commission of Shanxi Province","grant_id":"2023134","title":null},{"funder_name":"Health Commission of Shanxi Province","grant_id":"2020135","title":null},{"funder_name":"Health Commission of Shanxi Province","grant_id":"2023138","title":null},{"funder_name":"Changzhi Medical College Doctoral Initiation Fund","grant_id":"BS202009","title":null},{"funder_name":"Innovation and Entrepreneurship Training Program of Shanxi Province College Students","grant_id":"20220839","title":null},{"funder_name":"Innovation and Entrepreneurship Training Program of Shanxi Province College Students","grant_id":"20230826","title":null},{"funder_name":"Innovation and Entrepreneurship Training Program of Shanxi Province College Students","grant_id":"20240960","title":null},{"funder_name":"Innovation and Entrepreneurship Training Program of Shanxi Province College Students","grant_id":"20240966","title":null},{"funder_name":"Hunan Provincial Natural Science Foundation of China","grant_id":"2020JJ5517","title":null},{"funder_name":"Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research","grant_id":"2024sy006","title":null}],"total_grants":15,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s41105-025-00581-0.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s41105-025-00581-0/fulltext.html","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Synaptic plasticity","Linear regression analysis","Alzheimer’s disease","5-Ht Transmitter","Cognitive Function And Emotion"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T23:12:31.853674Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}