{"doi":"10.1007/s40618-022-01976-3","title":"Association between acrylamide exposure and sex hormones among premenopausal and postmenopausal women: NHANES, 2013–2016","abstract":null,"journal":"Journal of Endocrinological Investigation","year":2023,"id":631905,"datarank":0.272920188925982,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.031504502060866954,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.031504502060866954,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1637734,"name":"X. Deng","orcid":null,"position":1,"is_corresponding":false},{"id":612493,"name":"Q. Ma","orcid":null,"position":2,"is_corresponding":false},{"id":1637735,"name":"F. Ma","orcid":"0000-0002-7781-821X","position":3,"is_corresponding":false},{"id":10637,"name":"R. Wang","orcid":"0000-0001-9839-608X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association between acrylamide exposure and sex hormones among premenopausal and postmenopausal women: NHANES, 2013–2016","abstract":"<h4>Purpose</h4>Acrylamide (AA) is a potential carcinogen that mainly comes from fried, baked and roasted foods, and Hb adducts of AA (HbAA) and its metabolite glycidamide (HbGA) are the biomarkers of its exposure. Increasing evidence suggests that AA is associated with various hormone-related cancers. This study aims to explore the association of HbAA and HbGA with female serum sex hormone concentrations.<h4>Methods</h4>942 women from the National Health and Nutrition Examination Survey cycles (2013-2016) were included in this cross-sectional study. The associations between HbAA or HbGA or HbGA/HbAA and sex hormones were assessed by the multiple linear regression. Further stratified analyses were conducted to figure out the effects of menopausal status, BMI and smoking status on sex hormone levels.<h4>Results</h4>Among all participants, 597 were premenopausal and 345 were postmenopausal. HbAA was positively associated with both two androgen indicators. Specifically, a ln-unit increase in HbAA was associated with 0.41 ng/dL higher ln(total testosterone, TT) (95% CI 0.00, 0.27) and 0.14 ng/dL higher ln(free testosterone) (95%CI 0.00, 0.28), respectively. However, HbGA concentrations had no association with sex hormones in the overall population. Additionally, HbGA/HbAA was negatively associated with TT and SHBG in the overall population as well as postmenopausal women. In stratified analysis, higher HbAA was associated with rising TT in postmenopausal women (β = 0.29, 95%CI 0.04, 0.53) and underweight/normal-weight women (β = 0.18, 95%CI 0.03, 0.33). Other indicators had no significant association detected in estradiol and sex hormone-binding globulin.<h4>Conclusion</h4>Our results revealed that HbAA was positively associated with androgen concentrations, especially in postmenopausal and BMI < 25 women.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36602706","pmcid":null,"openalex_id":"https://openalex.org/W4313509676","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"31771662","title":null}],"total_grants":1,"fwci":0.4894,"citation_percentile":0.64681985,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s40618-022-01976-3.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s40618-022-01976-3/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s40618-022-01976-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36602706","host_type":"repository"}],"fields_of_study":["Potato Plant Research","Nutritional Studies and Diet","Edible Oils Quality and Analysis","Humans","Female","Nutrition Surveys","Hemoglobins","Acrylamide","Androgens","Cross-Sectional Studies","Postmenopause","Gonadal Steroid Hormones","Testosterone","Sex Hormone-Binding Globulin"],"mesh_terms":["Androgens","Cross-Sectional Studies","Female","Hemoglobins","Humans","Nutrition Surveys","Sex Hormone-Binding Globulin","Gonadal Steroid Hormones","Testosterone","Postmenopause","Acrylamide"],"keywords":["Medicine","Population","Sex hormone-binding globulin","Testosterone (patch)","Underweight","Cross-sectional study","Internal medicine","Physiology","Hormone","Endocrinology","Androgen","Body mass index","Environmental health","Overweight","Pathology","Testosterone","Sex hormone","Acrylamide","Menopausal Status"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T01:03:30.567039Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}