{"doi":"10.1007/s40618-021-01702-5","title":"Testosterone supplementation and bone parameters: a systematic review and meta-analysis study","abstract":null,"journal":"Journal of Endocrinological Investigation","year":2022,"id":605971,"datarank":0.6190701577567639,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6190701577567639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555433,"name":"W. Vena","orcid":null,"position":1,"is_corresponding":false},{"id":1555434,"name":"A. Pizzocaro","orcid":null,"position":2,"is_corresponding":false},{"id":1555435,"name":"V. A. Giagulli","orcid":null,"position":3,"is_corresponding":false},{"id":1555436,"name":"D. Francomano","orcid":null,"position":4,"is_corresponding":false},{"id":1555437,"name":"G. Rastrelli","orcid":null,"position":5,"is_corresponding":false},{"id":1555438,"name":"G. Mazziotti","orcid":null,"position":6,"is_corresponding":false},{"id":1555439,"name":"A. Aversa","orcid":null,"position":7,"is_corresponding":false},{"id":1555440,"name":"A. M. Isidori","orcid":null,"position":8,"is_corresponding":false},{"id":1555441,"name":"R. Pivonello","orcid":null,"position":9,"is_corresponding":false},{"id":1555442,"name":"L. Vignozzi","orcid":null,"position":10,"is_corresponding":false},{"id":1546623,"name":"E. Mannucci","orcid":null,"position":11,"is_corresponding":false},{"id":419982,"name":"Mario Maggi","orcid":"0000-0003-3267-4221","position":12,"is_corresponding":false},{"id":1555443,"name":"A. Ferlin","orcid":null,"position":13,"is_corresponding":false},{"id":1555432,"name":"G. Corona","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Testosterone supplementation and bone parameters: a systematic review and meta-analysis study","abstract":"<h4>Background</h4>The role of testosterone (T) replacement therapy (TRT) in subjects with late onset hypogonadism is still the object of an intense debate.<h4>Methods</h4>All observational studies and placebo-controlled or -uncontrolled randomized trials (RCTs) comparing the effect of TRT on different bone parameters were considered.<h4>Results</h4>Out of 349 articles, 36 were considered, including 3103 individuals with a mean trial duration of 66.6 weeks. TRT improves areal bone mineral density (aBMD) at the spine and femoral neck levels in observational studies, whereas placebo-controlled RTCs showed a positive effect of TRT only at lumber spine and when trials included only hypogonadal patients at baseline (total testosterone < 12 nM). The effects on aBMD were more evident in subjects with lower T levels at baseline and increased as a function of trial duration and a higher prevalence of diabetic subjects. Either T or estradiol increase at endpoint contributed to aBMD improvement. TRT was associated with a significant reduction of bone resorption markers in observational but not in controlled studies.<h4>Conclusion</h4>TRT is able to inhibit bone resorption and increase bone mass, particularly at the lumbar spine level and when the duration is long enough to allow the anabolic effect of T and estrogens on bone metabolism to take place.","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35041193","pmcid":null,"openalex_id":"https://openalex.org/W4206171882","authors":[],"funders":[],"total_grants":0,"fwci":3.3224,"citation_percentile":0.94090305,"influential_citations":0,"citation_trend":[{"year":2022,"count":8},{"year":2023,"count":16},{"year":2024,"count":12},{"year":2025,"count":18},{"year":2026,"count":7}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1007/s40618-021-01702-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35041193","host_type":"repository"},{"url":"https://hdl.handle.net/2158/1257032","host_type":"repository"},{"url":"http://hdl.handle.net/11577/3444083","host_type":"repository"}],"fields_of_study":["Hormonal and reproductive studies","Bone health and osteoporosis research","Menopause: Health Impacts and Treatments"],"mesh_terms":["Bone Resorption","Femur Neck","Humans","Hypogonadism","Lumbar Vertebrae","Testosterone","Bone Density","Dietary Supplements","Hormone Replacement Therapy"],"keywords":["Medicine","Placebo","Osteoporosis","Bone mineral","Femoral neck","Testosterone (patch)","Observational study","Bone remodeling","Trabecular bone score","Randomized controlled trial","Bone resorption","Internal medicine","Anabolism","Hormone replacement therapy (female-to-male)","Bone density","Endocrinology","Urology","Quantitative computed tomography","Pathology","Testosterone","Bone","Hypogonadism","bone mineral density","Late-onset Hypogonadism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:37:58.110188Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}