{"doi":"10.1007/s40520-025-03071-y","title":"The bidirectional association of malnutrition with depression and anxiety in patients with cancer: a systematic review and meta-analysis of evidence","abstract":null,"journal":"Aging Clinical and Experimental Research","year":2025,"id":662514,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1729548,"name":"Ewa Błaszczyk-Bębenek","orcid":null,"position":1,"is_corresponding":false},{"id":1729549,"name":"Aneta Cebula","orcid":null,"position":2,"is_corresponding":false},{"id":38685,"name":"Justyna Godos","orcid":"0000-0002-5809-5706","position":3,"is_corresponding":false},{"id":1729550,"name":"Kamil Konopka","orcid":null,"position":4,"is_corresponding":false},{"id":1729551,"name":"Anna Wąż","orcid":null,"position":5,"is_corresponding":false},{"id":284195,"name":"Giuseppe Grosso","orcid":"0000-0003-3930-5285","position":6,"is_corresponding":false},{"id":1729546,"name":"Agnieszka Micek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The bidirectional association of malnutrition with depression and anxiety in patients with cancer: a systematic review and meta-analysis of evidence","abstract":"BACKGROUND: Anxiety and depression are common mental health problems in cancer patients. At the same time, cancer patients often suffer from disease-related catabolic dysregulation and malnutrition. Emerging evidence has suggested the potential link between mental disorders and nutritional status. AIMS: This study summarised the evidence for the association of malnutrition with anxiety and depression in cancer patients. METHODS: A systematic search of PubMed and EMBASE databases was performed for observational studies published up to December 2024. RESULTS: Forty-one articles were found eligible for inclusion in the systematic review, and twenty-nine in the meta-analysis. Compared with the normally nourished cancer patients, malnourished patients had a more than threefold (relative risk (RR) = 3.23, 95% CI 2.39, 4.38) and nearly twofold (RR = 1.87, 95% CI 1.48, 2.37) increased risk of depression and anxiety, respectively. Considering the studies that identified lower emotional status as a cause rather than an effect of malnutrition, the inverse association was confirmed only for depression (RR = 2.01, 95% CI 1.62, 2.49), but not for anxiety (RR = 1.38, 95% CI 0.68, 2.80). Finally, the standardised mean differences of the psychological scores showed significantly higher values in individuals with nutritional impairment compared to those with normal nutritional status (SMD = 0.69, 95% CI 0.50, 0.88 for depression and SMD = 0.54, 95% CI 0.26, 0.82 for anxiety). CONCLUSIONS: Mental health problems such as anxiety and depression are associated with malnutrition in cancer patients.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40410541","pmcid":"PMC12102140","openalex_id":"https://openalex.org/W4410630898","authors":[],"funders":[],"total_grants":0,"fwci":3.8827,"citation_percentile":0.95132427,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":9}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s40520-025-03071-y.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s40520-025-03071-y.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s40520-025-03071-y/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s40520-025-03071-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40410541","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12102140","host_type":"repository"},{"url":"https://ruj.uj.edu.pl/handle/item/553239","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12102140/pdf/40520_2025_Article_3071.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12102140","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12102140?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Nutrition and Health in Aging","Cancer survivorship and care","Vitamin C and Antioxidants Research"],"mesh_terms":["Anxiety","Depression","Humans","Neoplasms","Nutritional Status","Malnutrition"],"keywords":["Meta-analysis","Depression (economics)","Anxiety","Malnutrition","Association (psychology)","Systematic review","Medicine","Cancer","MEDLINE","Psychiatry","Psychology","Clinical psychology","Internal medicine","Psychotherapist","Biology","Depression","nutritional status","Cancer Patients","Emotional Distress"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T15:30:24.984158Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}