{"doi":"10.1007/s40471-025-00375-5","title":"The Role of Glucagon-Like Peptide-1 Receptor Agonists in Post ST-Segment Elevation Myocardial Infarction Care: A Scoping Review","abstract":"Purpose of review: This scoping review synthesizes current evidence on glucagon-like peptide-1 receptor agonist (GLP-1RA) use after ST-elevation myocardial infarction (STEMI), highlighting their potential as adjunctive therapy. Recent findings: Ten studies investigated exenatide and liraglutide in adults with STEMI, evaluating imaging, clinical, mechanistic, and safety outcomes. GLP-1RA use was safe and well tolerated. Exenatide demonstrated improvements in infarct size, myocardial salvage, and cardiac function, although two trials in broader STEMI populations reported no post-infarction improvements. Across three trials, liraglutide was associated with improved myocardial salvage, infarct size, left ventricular ejection fraction, stroke volume and no-reflow, supported by favorable biomarker changes, but without significant reductions in major cardiovascular events. Summary: While most existing evidence is based on studies with limited generalizability, GLP-1RA use shows promise in improving post-STEMI outcomes. The consistent benefits reported support the need for larger, multicenter trials to clarify GLP-1RA role in cardioprotection and long-term outcomes.","journal":"Current Epidemiology Reports","year":2025,"id":548397,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9667,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1442082,"name":"Cynthia Paniagua","orcid":null,"position":1,"is_corresponding":false},{"id":423713,"name":"Julie Nguyen","orcid":"0000-0002-8361-0204","position":2,"is_corresponding":false},{"id":671311,"name":"Ana Kojic","orcid":"0000-0002-1829-9990","position":3,"is_corresponding":false},{"id":1442083,"name":"Elena Rose Sanfrey","orcid":null,"position":4,"is_corresponding":false},{"id":1442084,"name":"Madison Emilee Reyome","orcid":null,"position":5,"is_corresponding":false},{"id":1135088,"name":"Liliana Aguayo","orcid":"0000-0002-3496-0312","position":6,"is_corresponding":false},{"id":1185354,"name":"Elisabeth Lilian Pia Sattler","orcid":"0000-0002-6379-7892","position":7,"is_corresponding":false},{"id":1441582,"name":"Laura Ellen França Soares","orcid":"0000-0002-9254-8318","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T02:53:58.530220Z","pmid":"41230336","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}