{"doi":"10.1007/s40265-026-02294-1","title":"Mucus as a Treatable Trait in Chronic Airway Diseases","abstract":null,"journal":"Drugs","year":2026,"id":624061,"datarank":0.2781159061536678,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.00935198576945958,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.00935198576945958,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":4,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1531977,"name":"Paola Rogliani","orcid":"0000-0001-7801-5040","position":1,"is_corresponding":false},{"id":1613111,"name":"Josuel Ora","orcid":"0000-0001-9877-7851","position":2,"is_corresponding":false},{"id":1531975,"name":"Luigino Calzetta","orcid":"0000-0003-0456-069X","position":3,"is_corresponding":false},{"id":1531978,"name":"Maria Gabriella Matera","orcid":"0000-0002-5113-9235","position":4,"is_corresponding":false},{"id":13327,"name":"Mario Cazzola","orcid":"0000-0003-4895-9707","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mucus as a Treatable Trait in Chronic Airway Diseases","abstract":"Chronic airway diseases, including asthma, chronic obstructive pulmonary disease, bronchiectasis, and cystic fibrosis, are increasingly recognized as heterogeneous disorders characterized by overlapping pathophysiological mechanisms. Among these, abnormalities in mucus production, composition, and clearance have been identified as clinically significant contributors to symptoms, airflow limitation, exacerbations, and disease progression. Within the \"treatable traits\" framework, mucus-related abnormalities represent a distinct, modifiable phenotype that supports personalized management strategies. This narrative review explores mucus as a treatable trait across chronic airways diseases, integrating mechanistic insights with clinical assessment, biomarkers, and current and emerging therapeutic approaches. We discuss the role of mucus in disease phenotyping, its impact on morbidity, and the potential of targeted interventions to improve outcomes. Recognizing mucus as a treatable trait aligns with the principles of precision medicine and offers a pathway toward individualized therapy beyond traditional diagnostic labels.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41712061","pmcid":"PMC13005781","openalex_id":"https://openalex.org/W7130518798","authors":[],"funders":[{"funder_name":"Università degli Studi di Roma Tor Vergata","grant_id":"","title":null}],"total_grants":1,"fwci":27.8701,"citation_percentile":0.99600161,"influential_citations":0,"citation_trend":[{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s40265-026-02294-1.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s40265-026-02294-1.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s40265-026-02294-1","host_type":"publisher"},{"url":"https://doi.org/10.1007/s40265-026-02294-1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41712061","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13005781/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13005781","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13005781?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cystic Fibrosis Research Advances","Asthma and respiratory diseases","Chronic Obstructive Pulmonary Disease (COPD) Research"],"mesh_terms":["Asthma","Bronchiectasis","Chronic Disease","Cystic Fibrosis","Humans","Mucus","Phenotype","Biomarkers","Pulmonary Disease, Chronic Obstructive","Precision Medicine"],"keywords":["Mucus","Cystic fibrosis","Mucociliary clearance","Narrative review","Airway","COPD","Microbiome","Disease","Psychological intervention","Clinical phenotype"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T02:30:04.647418Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}