{"doi":"10.1007/s13353-025-00973-5","title":"Gene therapy strategies in ophthalmology—an overview of current developments and future prospects","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Gene therapies have recently emerged as promising strategies for treatment of previously incurable or poorly managed diseases. These hopes are particularly high in ophthalmology, as the eye is considered exceptionally suited for gene therapy. Expansion of gene therapy products may change the clinical course of treatment and give new chances to many patients. In this review, we address treatment possibilities and delivery methods as well as challenges and uncertainties related to gene therapy. We present inherited and acquired diseases which are subject to studies within this area, summarize current trends in ocular gene therapy, and indicate the future directions.</jats:p>","journal":"Journal of Applied Genetics","year":2026,"id":632405,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1639274,"name":"Arleta Waszczykowska","orcid":"0000-0002-4950-6390","position":1,"is_corresponding":false},{"id":1639273,"name":"Julia B. Krajewska","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gene therapy strategies in ophthalmology—an overview of current developments and future prospects","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Gene therapies have recently emerged as promising strategies for treatment of previously incurable or poorly managed diseases. These hopes are particularly high in ophthalmology, as the eye is considered exceptionally suited for gene therapy. Expansion of gene therapy products may change the clinical course of treatment and give new chances to many patients. In this review, we address treatment possibilities and delivery methods as well as challenges and uncertainties related to gene therapy. We present inherited and acquired diseases which are subject to studies within this area, summarize current trends in ocular gene therapy, and indicate the future directions.</jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40471435","pmcid":"PMC13079547","openalex_id":"https://openalex.org/W4411070236","authors":[],"funders":[],"total_grants":0,"fwci":4.424,"citation_percentile":0.95191305,"influential_citations":0,"citation_trend":[{"year":2025,"count":4},{"year":2026,"count":7}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s13353-025-00973-5.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s13353-025-00973-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s13353-025-00973-5","host_type":"publisher"},{"url":"https://doi.org/10.1007/s13353-025-00973-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40471435","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13079547/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13079547","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13079547?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Retinal Development and Disorders","Ocular Disorders and Treatments","Corneal Surgery and Treatments"],"mesh_terms":["Eye Diseases","Genetic Vectors","Humans","Ophthalmology","Genetic Therapy","Gene Transfer Techniques"],"keywords":["Genetic enhancement","Biology","Gene delivery","Intensive care medicine","Bioinformatics","Gene","Computational biology","Medicine","Genetics","Gene therapy","Ocular diseases","Drug Development","Gene Editing"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:42:03.579730Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}