{"doi":"10.1007/s13277-015-4667-5","title":"Contributions of phosphatidylserine-positive platelets and leukocytes and microparticles to hypercoagulable state in gastric cancer patients","abstract":null,"journal":"Tumor Biology","year":2016,"id":683657,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1748939,"name":"Ruishuang Ma","orcid":"0000-0003-4288-9883","position":1,"is_corresponding":false},{"id":883227,"name":"Tao Jiang","orcid":"0000-0002-8529-4487","position":2,"is_corresponding":false},{"id":1785972,"name":"Muhua Cao","orcid":null,"position":3,"is_corresponding":false},{"id":1785974,"name":"Liangliang Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":1785976,"name":"Yayan Bi","orcid":null,"position":5,"is_corresponding":false},{"id":1785978,"name":"Junjie Kou","orcid":null,"position":6,"is_corresponding":false},{"id":580629,"name":"Jialan Shi","orcid":"0000-0001-5642-5436","position":7,"is_corresponding":false},{"id":1785979,"name":"Xiaoming Zou","orcid":null,"position":8,"is_corresponding":false},{"id":1785970,"name":"Chunfa Yang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Contributions of phosphatidylserine-positive platelets and leukocytes and microparticles to hypercoagulable state in gastric cancer patients","abstract":"Hypercoagulability in gastric cancer is a common complication and a major contributor to poor prognosis. This study aimed to determine procoagulant activity of blood cells and microparticles (MPs) in gastric cancer patients. Phosphatidylserine-positive blood cells and MPs, and their procoagulant properties in particular, were assessed in 48 gastric cancer patients and 35 healthy controls. Phosphatidylserine-positive platelets, leukocytes, and MPs in patients with tumor-node-metastasis stage III/IV gastric cancer were significantly higher than those in stage I/II patients or healthy controls. Moreover, procoagulant activity of platelets, leukocytes, and MPs in stage III/IV patients was significantly increased compared to the controls, as indicated by shorter clotting time, higher intrinsic and extrinsic factor tenase, and prothrombinase complex activity. Interestingly, lactadherin, which competes with factors V and VIII to bind phosphatidylserine, dramatically prolonged clotting time of the cells and MPs by inhibiting factor tenase and prothrombinase complex activity. Although anti-tissue factor antibody significantly attenuated extrinsic tenase complex activity of leukocytes and MPs, it only slightly prolonged clotting times. Meanwhile, treatment with radical resection reduced phosphatidylserine-positive platelets, leukocytes, and MPs, and prolonged the clotting times of the remaining cells and MPs. Our results suggest that phosphatidylserine-positive platelets, leukocytes, and MPs contribute to hypercoagulability and represent a potential therapeutic target to prevent coagulation in patients with stage III/IV gastric cancer.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26700666","pmcid":null,"openalex_id":"https://openalex.org/W2209914515","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China (CN)","grant_id":"81270588","title":null}],"total_grants":1,"fwci":1.9889,"citation_percentile":0.87048221,"influential_citations":0,"citation_trend":[{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s13277-015-4667-5.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s13277-015-4667-5/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s13277-015-4667-5","host_type":"publisher"},{"url":"https://doi.org/10.1007/s13277-015-4667-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26700666","host_type":"repository"}],"fields_of_study":["Platelet Disorders and Treatments","Phagocytosis and Immune Regulation","Blood Coagulation and Thrombosis Mechanisms"],"mesh_terms":["Adult","Blood Coagulation","Blood Platelets","Female","Flow Cytometry","Humans","Leukocytes","Male","Middle Aged","Phosphatidylserines","Prospective Studies","Stomach Neoplasms","Thrombophilia","Cell-Derived Microparticles"],"keywords":["Phosphatidylserine","Prothrombinase","Cancer","Platelet","Tissue factor","Cancer cell","Medicine","Coagulation","Cancer research","Apoptosis","Immunology","Factor VII","Internal medicine","Thrombin","Chemistry","Biochemistry","Gastric cancer","Microparticles","Prothrombotic State"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T11:46:10.435138Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}