{"doi":"10.1007/s12551-021-00831-8","title":"What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm","abstract":null,"journal":"Biophysical Reviews","year":2021,"id":651436,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":859188,"name":"T. Alexander Quinn","orcid":"0000-0002-2437-5785","position":1,"is_corresponding":false},{"id":1698949,"name":"Eilidh A MacDonald","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm","abstract":"The rhythmic and spontaneously generated electrical excitation that triggers the heartbeat originates in the sinoatrial node (SAN). SAN automaticity has been thoroughly investigated, which has uncovered fundamental mechanisms involved in cardiac pacemaking that are generally categorised into two interacting and overlapping systems: the 'membrane' and 'Ca<sup>2+</sup> clock'. The principal focus of research has been on these two systems of oscillators, which have been studied primarily in single cells and isolated tissue, experimental preparations that do not consider mechanical factors present in the whole heart. SAN mechano-sensitivity has long been known to be a contributor to SAN pacemaking-both as a driver and regulator of automaticity-but its essential nature has been underappreciated. In this review, following a description of the traditional 'clocks' of SAN automaticity, we describe mechanisms of SAN mechano-sensitivity and its vital role for SAN function, making the argument that the 'mechanics oscillator' is, in fact, the 'grandfather clock' of cardiac rhythm.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34777615","pmcid":"PMC8555057","openalex_id":"https://openalex.org/W3199737834","authors":[],"funders":[{"funder_name":"natural sciences and engineering research council of canada","grant_id":"RGPIN-2016-04879","title":null},{"funder_name":"heart and stroke foundation of canada","grant_id":"G-18-0022185","title":null},{"funder_name":"canadian institutes of health research","grant_id":"MOP 342562","title":null},{"funder_name":"British Heart Foundation","grant_id":"RG/20/6/35095","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":5,"fwci":2.0452,"citation_percentile":0.88520049,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":1},{"year":2026,"count":5}],"oa_status":"green","license":"cc-by-sa","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s12551-021-00831-8.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s12551-021-00831-8/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s12551-021-00831-8","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34777615","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8555057","host_type":"repository"},{"url":"https://eprints.gla.ac.uk/259706/2/259706.pdf","host_type":""},{"url":"https://dx.doi.org/10.1007/s12551-021-00831-8","host_type":""}],"fields_of_study":["Cardiac electrophysiology and arrhythmias","Ion channel regulation and function","Neuroscience and Neural Engineering","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Sinoatrial node","Heartbeat","Automaticity","Rhythm","Neuroscience","Cardiac pacemaker","Biological clock","Cardiology","Cardiac cycle","Chronobiology","Heart Rhythm","Medicine","Heart rate","Internal medicine","Psychology","Circadian rhythm","Computer science","Blood pressure","Computer security","Stretch","Pacemaking","Mechano-electric Coupling","Calcium Clock","Membrane Clock"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T09:26:09.275781Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}