{"doi":"10.1007/s12282-024-01546-w","title":"Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer","abstract":null,"journal":"Breast Cancer","year":2024,"id":616577,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1589750,"name":"Hiromi Fuchikami","orcid":null,"position":1,"is_corresponding":false},{"id":1589752,"name":"Naoko Takeda","orcid":null,"position":2,"is_corresponding":false},{"id":1589753,"name":"Nana Natsume","orcid":null,"position":3,"is_corresponding":false},{"id":1589755,"name":"Masahiro Kato","orcid":null,"position":4,"is_corresponding":false},{"id":137760,"name":"Kazuhiko Sato","orcid":"0000-0002-0380-1693","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer","abstract":"<h4>Purpose</h4>Perioperative partial-breast irradiation (PBI) with multicatheter interstitial brachytherapy (MIB) is less invasive and more convenient than postoperative one. This study aimed to compare ultrashort perioperative MIB-PBI (uPBI) and conventional perioperative MIB-PBI (cPBI) performed during the same period of time.<h4>Methods</h4>Inclusion criteria of the study were patients aged ≥ 40 years and those with T0-2 (≤ 3 cm), N0-mi, and negative margins on mammography. The locoregional recurrence (LRR) and toxicity rates were compared between uPBI at a dose of 25.2 Gy in four fractions and cPBI at a dose of 32 Gy in eight fractions.<h4>Results</h4>In total, 198 patients (151 with uPBI and 47 with cPBI) were evaluated. At a median follow-up of 20.1 months, one (0.66%) patient in the uPBI group had LRR. The 2-year ipsilateral breast tumor recurrence-free survival rates of the uPBI and cPBI groups were 98.7% and 100%, respectively. The highest toxicity grades were grade 1 in 23 (15.2%) and grade 2 in 2 (1.3%) patients in the uPBI group, and grade 1 in 8 (17.0%) and grade 2 in 1 (2.1%) patient in the cPBI group. None of the patients in the two groups presented with grade 3 and higher toxicities. The toxicity rates between the two groups did not significantly differ. Further, 22 (14.6%) patients in the uPBI group and 8 (17.0%) in the cPBI group, and 3 (2.0%) patients in the uPBI group and 1 (2.1%) in the cPBI had acute and late toxicities, respectively. The timing of toxicity development between the two groups did not significantly differ.<h4>Conclusions</h4>Although this preliminary report included a small sample size and had a short follow-up period, the local control and toxicity rates were similar between the uPBI and cPBI groups. Further research is warranted to investigate the ideal dose schedule of MIB-PBI.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38363473","pmcid":null,"openalex_id":"https://openalex.org/W4391883203","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"5R01DC001158-03","title":"DYNAMIC ASPECTS OF THE LARYNGEAL NEUROMUSCULAR SYSTEM"}],"total_grants":1,"fwci":0.3639,"citation_percentile":0.53468128,"influential_citations":0,"citation_trend":[{"year":2025,"count":2}],"oa_status":"closed","license":"Springer Nature TDM","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s12282-024-01546-w.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s12282-024-01546-w/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s12282-024-01546-w","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38363473","host_type":"repository"},{"url":"https://doi.org/10.21203/rs.3.rs-3371340/v1","host_type":""}],"fields_of_study":["Breast Cancer Treatment Studies","Breast Implant and Reconstruction","Breast Lesions and Carcinomas","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Brachytherapy","Breast Neoplasms","Female","Follow-Up Studies","Humans","Middle Aged","Neoplasm Recurrence, Local","Neoplasm Staging","Retrospective Studies","Mastectomy, Segmental","Disease-Free Survival"],"keywords":["Medicine","Perioperative","Brachytherapy","Breast cancer","Surgical oncology","Stage (stratigraphy)","Nuclear medicine","Toxicity","Surgery","Urology","Cancer","Radiation therapy","Internal medicine","Breast-conserving Therapy","Partial-breast Irradiation","Multicatheter Interstitial Brachytherapy","Ultrashort Hypofraction Regimen","Adult","Aged, 80 and over","Breast Neoplasms","Middle Aged","Mastectomy, Segmental","Disease-Free Survival","Humans","Female","Neoplasm Recurrence, Local","Aged","Follow-Up Studies","Neoplasm Staging","Retrospective Studies"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T23:15:23.653671Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}