{"doi":"10.1007/s12272-020-01263-w","title":"Many faces of the GPCR-arrestin interaction","abstract":null,"journal":"Archives of Pharmacal Research","year":2020,"id":615468,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":339932,"name":"Ka Young Chung","orcid":"0000-0001-9038-9571","position":1,"is_corresponding":false},{"id":1586390,"name":"Kiae Kim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Many faces of the GPCR-arrestin interaction","abstract":"G protein-coupled receptors (GPCRs) belong to a major receptor family and regulate important physiological and pathological functions. Upon agonist activation, GPCRs couple to G proteins and induce the activation of G protein-dependent signaling pathways. The agonist-activated GPCRs are also phosphorylated by G protein-coupled receptor kinases (GRKs), which promote their interaction with arrestins. Arrestin binding induces desensitization (i.e., inability to couple to G proteins) and/or internalization of GPCRs. Arrestins not only desensitize and/or internalize GPCRs but also mediate other downstream signals such as mitogen-activated protein kinases. G protein-mediated signaling and arrestin-mediated signaling often result in different functional outcomes, and therefore, it has been suggested that signaling-selective regulation of GPCRs could lead to the development of more effective treatments with fewer side effects. Thus, studies have attempted to develop functionally biased (i.e., signaling-selective) GPCR-targeting drugs. To this end, it is important to elucidate the structural mechanism underlying functionally biased GPCR signaling, which includes understanding the structural mechanism underlying the GPCR-arrestin interaction. This review aims discuss the structural aspects of the GPCR-arrestin interaction, focusing on the differences between reported GPCR-arrestin complex structures.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32803684","pmcid":null,"openalex_id":"https://openalex.org/W3049722152","authors":[],"funders":[{"funder_name":"Ministry of Science and ICT","grant_id":"2018R1A2B6001554","title":null},{"funder_name":"Ministry of Science and ICT","grant_id":"2019R1A5A2027340","title":null}],"total_grants":2,"fwci":0.9692,"citation_percentile":0.73653489,"influential_citations":0,"citation_trend":[{"year":2021,"count":7},{"year":2022,"count":1},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s12272-020-01263-w.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s12272-020-01263-w/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s12272-020-01263-w","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32803684","host_type":"repository"}],"fields_of_study":["Receptor Mechanisms and Signaling","Neuropeptides and Animal Physiology","Renin-Angiotensin System Studies"],"mesh_terms":["Protein Conformation, alpha-Helical","Protein Conformation, beta-Strand","Animals","Humans","Phosphorylation","Crystallography, X-Ray","Arrestins","MAP Kinase Signaling System","Receptors, G-Protein-Coupled","G-Protein-Coupled Receptor Kinases"],"keywords":["G protein-coupled receptor","Arrestin","G protein-coupled receptor kinase","Internalization","Cell biology","Signal transduction","G protein","Functional selectivity","Biology","Rhodopsin-like receptors","Receptor","Agonist","Chemistry","Biochemistry","Metabotropic receptor","Structure","Gpcr"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Gender equality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:06:53.622001Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}