{"doi":"10.1007/s12265-021-10147-3","title":"The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice","abstract":"Angiotensin-converting enzyme 2 (ACE2) is required for the cellular entry of the severe acute respiratory syndrome coronavirus 2. ACE2, via the Ang-(1-7)-Mas-R axis, is part of the antihypertensive and cardioprotective effects of the renin-angiotensin system. We studied hospitalized COVID-19 patients with hypertension and hypertensive human(h) ACE2 transgenic mice to determine the outcome of COVID-19 with or without AT1 receptor (AT1R) blocker treatment. The severity of the illness and the levels of serum cardiac biomarkers (CK, CK-BM, cTnI), as well as the inflammation markers (IL-1, IL-6, CRP), were lesser in hypertensive COVID-19 patients treated with AT1R blockers than those treated with other antihypertensive drugs. Hypertensive hACE2 transgenic mice, pretreated with AT1R blocker, had increased ACE2 expression and SARS-CoV-2 in the kidney and heart, 1 day post-infection. We conclude that those hypertensive patients treated with AT1R blocker may be at higher risk for SARS-CoV-2 infection. However, AT1R blockers had no effect on the severity of the illness but instead may have protected COVID-19 patients from heart injury, via the ACE2-angiotensin1-7-Mas receptor axis.","journal":"Journal of Cardiovascular Translational Research","year":2022,"id":289114,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9644,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":103933,"name":"Huadong Li","orcid":"0000-0001-7085-9775","position":1,"is_corresponding":false},{"id":815040,"name":"Yong Liu","orcid":"0000-0001-7395-4153","position":2,"is_corresponding":false},{"id":970296,"name":"Linlin Bao","orcid":"0000-0003-4869-3777","position":3,"is_corresponding":false},{"id":970297,"name":"Lingjun Zhan","orcid":"0000-0002-4486-9424","position":4,"is_corresponding":false},{"id":31762,"name":"Hong Gao","orcid":"0000-0002-2488-8695","position":5,"is_corresponding":false},{"id":970298,"name":"Wei Deng","orcid":"0000-0002-1619-2313","position":6,"is_corresponding":false},{"id":965054,"name":"Jing Xue","orcid":"0000-0002-9113-2433","position":7,"is_corresponding":false},{"id":970777,"name":"Jiangning Liu","orcid":null,"position":8,"is_corresponding":false},{"id":970299,"name":"Xing Liu","orcid":"0000-0003-1036-5858","position":9,"is_corresponding":false},{"id":717210,"name":"Junli Li","orcid":"0000-0001-5542-3375","position":10,"is_corresponding":false},{"id":970300,"name":"Jie Wang","orcid":"0000-0002-5812-6082","position":11,"is_corresponding":false},{"id":970301,"name":"Shuang Wu","orcid":"0000-0003-2420-0165","position":12,"is_corresponding":false},{"id":970778,"name":"Mingzhe Yan","orcid":null,"position":13,"is_corresponding":false},{"id":248965,"name":"Wei Luo","orcid":"0000-0002-8465-5607","position":14,"is_corresponding":false},{"id":332117,"name":"Pedro A. José","orcid":"0000-0003-1507-7556","position":15,"is_corresponding":false},{"id":7613,"name":"Chuan Qin","orcid":"0000-0002-6261-1232","position":16,"is_corresponding":false},{"id":970302,"name":"Xiuhong Yang","orcid":"0000-0002-7463-8926","position":17,"is_corresponding":false},{"id":6076,"name":"Dingyu Zhang","orcid":"0000-0002-9277-5705","position":18,"is_corresponding":false},{"id":970303,"name":"Zhiwei Yang","orcid":"0000-0001-6943-004X","position":19,"is_corresponding":false},{"id":713302,"name":"Xiaoliang Jiang","orcid":"0000-0001-6010-343X","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T00:30:18.766838Z","pmid":"34973134","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}