{"doi":"10.1007/s12265-021-10114-y","title":"Myocardial Injury Promotes Matrix Metalloproteinase-9 Activity in the Renal Cortex in Preclinical Models of Acute Myocardial Infarction","abstract":"New mechanistic insight into how the kidney responds to cardiac injury during acute myocardial infarction (AMI) is required. We hypothesized that AMI promotes inflammation and matrix metalloproteinase-9 (MMP9) activity in the kidney and studied the effect of initiating an Impella CP or veno-arterial extracorporeal membrane oxygenation (VA-ECMO) before coronary reperfusion during AMI. Adult male swine were subjected to coronary occlusion and either reperfusion (ischemia-reperfusion; IR) or support with either Impella or VA-ECMO before reperfusion. IR and ECMO increased while Impella reduced levels of MMP-9 in the myocardial infarct zone, circulation, and renal cortex. Compared to IR, Impella reduced myocardial infarct size and urinary KIM-1 levels, but VA-ECMO did not. IR and VA-ECMO increased pro-fibrogenic signaling via transforming growth factor-beta and endoglin in the renal cortex, but Impella did not. These findings identify that AMI increases inflammatory activity in the kidney, which may be attenuated by Impella support.","journal":"Journal of Cardiovascular Translational Research","year":2021,"id":199912,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9677,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275864,"name":"Shreyas Bhave","orcid":"0000-0003-0393-0978","position":1,"is_corresponding":false},{"id":275862,"name":"Lija Swain","orcid":"0000-0001-7713-606X","position":2,"is_corresponding":false},{"id":230581,"name":"Elric Zweck","orcid":"0000-0001-6739-476X","position":3,"is_corresponding":false},{"id":275863,"name":"Lara Reyelt","orcid":"0000-0001-6242-5926","position":4,"is_corresponding":false},{"id":276735,"name":"Paige Crowley","orcid":null,"position":5,"is_corresponding":false},{"id":777607,"name":"Shiva Annamalai","orcid":null,"position":6,"is_corresponding":false},{"id":777608,"name":"Aditya Chennjorwala","orcid":null,"position":7,"is_corresponding":false},{"id":235131,"name":"Michele Esposito","orcid":"0000-0002-9017-9037","position":8,"is_corresponding":false},{"id":777609,"name":"Allen A Razavi","orcid":null,"position":9,"is_corresponding":false},{"id":776980,"name":"Sina Foroutanjazi","orcid":"0000-0002-8384-2945","position":10,"is_corresponding":false},{"id":777610,"name":"Cody Machen","orcid":null,"position":11,"is_corresponding":false},{"id":230579,"name":"Katherine Thayer","orcid":"0000-0002-0848-5853","position":12,"is_corresponding":false},{"id":238611,"name":"Lena Jorde","orcid":null,"position":13,"is_corresponding":false},{"id":275865,"name":"Richard H. Karas","orcid":"0000-0001-7799-091X","position":14,"is_corresponding":false},{"id":230592,"name":"Navin K. Kapur","orcid":"0000-0002-8302-6796","position":15,"is_corresponding":false},{"id":155920,"name":"Xiaoying Qiao","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:50:44.479665Z","pmid":"33782857","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}