{"doi":"10.1007/s12098-025-05882-3","title":"Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India","abstract":null,"journal":"Indian Journal of Pediatrics","year":2026,"id":632440,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":923688,"name":"Alpesh Goyal","orcid":"0000-0003-0922-5022","position":1,"is_corresponding":false},{"id":670914,"name":"Uma Kanga","orcid":"0000-0001-9437-0835","position":2,"is_corresponding":false},{"id":518113,"name":"Neeraj Kumar","orcid":"0000-0003-4222-2851","position":3,"is_corresponding":false},{"id":1639373,"name":"Dona Maria Philips","orcid":null,"position":4,"is_corresponding":false},{"id":462199,"name":"Pradeep A. Praveen","orcid":null,"position":5,"is_corresponding":false},{"id":1639374,"name":"Ravinder Goswami","orcid":null,"position":6,"is_corresponding":false},{"id":22843,"name":"Nikhil Tandon","orcid":"0000-0003-4604-1986","position":7,"is_corresponding":false},{"id":1637638,"name":"Shreya Sharma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India","abstract":"<h4>Objectives</h4>To determine the prevalence and persistence of islet autoantibodies and explore their HLA associations among patients with type 1 diabetes (T1DM).<h4>Methods</h4>Islet autoantibodies (GAD-65A, IA-2A, and ZnT8A) and fasting C-peptide (FCP) levels were assessed at baseline (prevalence) and 2-5 y, 5-10 y, and > 10 y from the baseline (persistence). HLA associations were evaluated for individual islet autoantibodies and their persistence.<h4>Results</h4>The authors evaluated 366 participants with a median diabetes duration of 6 y at baseline. The overall positivity for any of the three autoantibodies was 67.5%, which increased to 76% in a subset of patients (n = 125) with diabetes duration ≤ 2 y. In the persistence analysis, positivity for IA-2A and ZnT8A declined earlier compared to GAD-65A (median survival times of 11, 12, and 31 y). The median survival time for FCP (time to undetectable levels) was 5 y, with significantly shorter survival in individuals with younger (< 10 y) age at diagnosis and in the autoantibody-positive group. The HLA-DRB1*03 allele was significantly associated with the GAD-65A, and the HLA-DRB1*04 allele with the ZnT8A. There was no association of HLA-DRB1 status with islet autoantibody persistence.<h4>Conclusions</h4>Nearly two in every three patients evaluated at a median disease duration of 6 y tested positive for one or more islet autoantibodies. GAD-65A was more prevalent and relatively stable over time, serving as a robust diagnostic marker for T1DM. A more rapid decline in beta cell reserve was noted in individuals with younger age at diagnosis and islet autoantibody positivity.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41385070","pmcid":null,"openalex_id":"https://openalex.org/W4417304354","authors":[],"funders":[{"funder_name":"Indian Council of Medical Research","grant_id":"Indian Council of Medical Research","title":null},{"funder_name":"Endocrine Society of India","grant_id":"Endocrine Society of India","title":null}],"total_grants":2,"fwci":0.9754,"citation_percentile":0.81854922,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s12098-025-05882-3.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s12098-025-05882-3","host_type":"publisher"},{"url":"https://doi.org/10.1007/s12098-025-05882-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41385070","host_type":"repository"}],"fields_of_study":["Diabetes and associated disorders","Pancreatic function and diabetes","T-cell and B-cell Immunology","Humans","Diabetes Mellitus, Type 1","Autoantibodies","Child","India","Male","Female","Child, Preschool","Islets of Langerhans","Adolescent","Zinc Transporter 8","C-Peptide","HLA-DRB1 Chains","Glutamate Decarboxylase"],"mesh_terms":["Zinc Transporter 8","Adolescent","Autoantibodies","C-Peptide","Child","Child, Preschool","Diabetes Mellitus, Type 1","Female","Glutamate Decarboxylase","Humans","India","Islets of Langerhans","Male","HLA-DRB1 Chains"],"keywords":["Autoantibody","Islet","Type 1 diabetes","Persistence (discontinuity)","HLA-DQ","Disease","Diabetes mellitus","Persistence","HLA","C-peptide","Gad-65","Islet Autoantibody"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:45:36.599240Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}