{"doi":"10.1007/s12035-024-04315-0","title":"The Link Between Matrix Metalloproteinases and Alzheimer’s Disease Pathophysiology","abstract":"<jats:title>Abstract</jats:title><jats:p>Alzheimer’s disease (AD) is a major contributor to dementia and the most common neurodegenerative disorder. In AD pathophysiology, matrix metalloproteinases (MMPs)—proteolytic enzymes, best known to be responsible for remodeling and degradation of the extracellular matrix—were suggested to play an important role. Due to the diverse nature of the published data and frequent inconsistent results presented in available papers, it was considered essential to analyze all aspects of MMP literature with respect to AD pathophysiology and attempt to outline a unifying concept for understanding their role in AD. Thus, the main contribution of this review article is to summarize the most recent research on the participation of MMP in AD pathophysiology obtained using the cell cultures to understand the molecular principles of their action. Furthermore, an updated comprehensive view regarding this topic based exclusively on papers from human studies is provided as well. It can be concluded that determining the exact role of any particular MMPs in the AD pathophysiology holds promise for establishing their role as potential biomarkers reflecting the severity or progression of this disease or for developing new therapeutic agents targeting the processes that lead to AD.</jats:p>","journal":"Molecular Neurobiology","year":2025,"id":643169,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1673339,"name":"Jana Radosinska","orcid":"0000-0001-6703-5863","position":1,"is_corresponding":false},{"id":1673338,"name":"Dominika Radosinska","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Link Between Matrix Metalloproteinases and Alzheimer’s Disease Pathophysiology","abstract":"<jats:title>Abstract</jats:title><jats:p>Alzheimer’s disease (AD) is a major contributor to dementia and the most common neurodegenerative disorder. In AD pathophysiology, matrix metalloproteinases (MMPs)—proteolytic enzymes, best known to be responsible for remodeling and degradation of the extracellular matrix—were suggested to play an important role. Due to the diverse nature of the published data and frequent inconsistent results presented in available papers, it was considered essential to analyze all aspects of MMP literature with respect to AD pathophysiology and attempt to outline a unifying concept for understanding their role in AD. Thus, the main contribution of this review article is to summarize the most recent research on the participation of MMP in AD pathophysiology obtained using the cell cultures to understand the molecular principles of their action. Furthermore, an updated comprehensive view regarding this topic based exclusively on papers from human studies is provided as well. It can be concluded that determining the exact role of any particular MMPs in the AD pathophysiology holds promise for establishing their role as potential biomarkers reflecting the severity or progression of this disease or for developing new therapeutic agents targeting the processes that lead to AD.</jats:p>","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38935232","pmcid":"PMC11711632","openalex_id":"https://openalex.org/W4400086435","authors":[],"funders":[{"funder_name":"Comenius University in Bratislava","grant_id":"","title":null}],"total_grants":1,"fwci":7.3783,"citation_percentile":0.98215275,"influential_citations":0,"citation_trend":[{"year":2024,"count":4},{"year":2025,"count":22},{"year":2026,"count":14}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s12035-024-04315-0.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s12035-024-04315-0.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s12035-024-04315-0/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s12035-024-04315-0","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38935232","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11711632","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11711632/pdf/12035_2024_Article_4315.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11711632","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11711632?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Protease and Inhibitor Mechanisms","Alzheimer's disease research and treatments","Peptidase Inhibition and Analysis","Animals","Humans","Alzheimer Disease","Extracellular Matrix","Matrix Metalloproteinases"],"mesh_terms":["Alzheimer Disease","Animals","Extracellular Matrix","Humans","Matrix Metalloproteinases"],"keywords":["Pathophysiology","Disease","Neuroscience","Matrix metalloproteinase","Dementia","Neurology","Medicine","Bioinformatics","Psychology","Biology","Pathology","Internal medicine","Cell cultures","Amyloid","Biomarker","Alzheimer’s disease","matrix metalloproteinases","Human Samples"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T13:33:04.499080Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}