{"doi":"10.1007/s12033-024-01126-5","title":"Exploring Epigenetic and Genetic Modulation in Animal Responses to Thermal Stress","abstract":null,"journal":"Molecular Biotechnology","year":2025,"id":612773,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1577906,"name":"Sayed Haidar Abbas Raza","orcid":"0000-0002-0961-1911","position":1,"is_corresponding":false},{"id":1577907,"name":"Sameer D. Pant","orcid":null,"position":2,"is_corresponding":false},{"id":1577908,"name":"Zhao Juan","orcid":null,"position":3,"is_corresponding":false},{"id":1061432,"name":"Ajit Prakash","orcid":"0000-0001-7628-0457","position":4,"is_corresponding":false},{"id":1437950,"name":"Sameh A. Abdelnour","orcid":"0000-0002-6873-0718","position":5,"is_corresponding":false},{"id":1577909,"name":"Bandar Hamad Aloufi","orcid":null,"position":6,"is_corresponding":false},{"id":1577910,"name":"Zeinab M. H. Mahasneh","orcid":null,"position":7,"is_corresponding":false},{"id":1577911,"name":"Ahmed A. Amin","orcid":null,"position":8,"is_corresponding":false},{"id":1577912,"name":"Borhan Shokrollahi","orcid":null,"position":9,"is_corresponding":false},{"id":1577913,"name":"Linsen Zan","orcid":"0000-0002-2645-0179","position":10,"is_corresponding":false},{"id":1577905,"name":"Wang Jianfang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exploring Epigenetic and Genetic Modulation in Animal Responses to Thermal Stress","abstract":"There is increasing evidence indicating that global temperatures are rising significantly, a phenomenon commonly referred to as 'global warming', which in turn is believed to be causing drastic changes to the global climate. Global warming (GW) directly impacts animal health, reproduction, production, and welfare, presenting several challenges to livestock enterprises. Thermal stress (TS) is one of the key consequences of GW, and all animal species, including livestock, have diverse physiological, epigenetic and genetic mechanisms to respond to TS. As a result, TS can significantly affect an animals' health, immune responsiveness, metabolic pathways etc. which can also influence the productivity, performance, and welfare of animals. Moreover, prolonged exposure to TS can lead to transgenerational and intergenerational changes that are mediated by epigenetic changes. For example, in several animal species, the effects of TS are encoded epigenetically during the animals' growth or productive stage, and these epigenetic changes can be transmitted intergenerationally. Such epigenetic changes can affect animal productivity by changing the phenotype so that it aligns with its ancestors' environment, irrespective of its immediate environment. Furthermore, epigenetic and genetic changes can also help protect cells from the adverse effects of TS by modulating the transcriptional status of heat-responsive genes in animals. This review focuses on the genetic and epigenetic modulation and regulation that occurs in TS conditions via HSPs, histone alterations and DNA methylation.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38528286","pmcid":null,"openalex_id":"https://openalex.org/W4393139019","authors":[],"funders":[{"funder_name":"This work was supported by the National Beef and Yak Industrial Technology System (grant numbers CARS-37), Key Research and Development Program of Shaanxi Province (grant numbers 2022NY-050, 2022ZDLNY01-01), National Natural Science Foundation of China (gr","grant_id":"2060404-51301","title":null}],"total_grants":1,"fwci":5.0395,"citation_percentile":0.96131667,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":12},{"year":2026,"count":7}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s12033-024-01126-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s12033-024-01126-5/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s12033-024-01126-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38528286","host_type":"repository"}],"fields_of_study":["Effects of Environmental Stressors on Livestock","Adipose Tissue and Metabolism","Physiological and biochemical adaptations"],"mesh_terms":["Animals","Heat-Shock Proteins","Histones","Heat-Shock Response","DNA Methylation","Epigenesis, Genetic","Global Warming","Livestock"],"keywords":["Epigenetics","Biology","Genetics","DNA methylation","Histone","Livestock","Phenotype","Epigenesis","Productivity","Gene","Ecology","Gene expression","Animals","Heat stress","Epigenetic Modifications","Molecular Changes"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T04:54:36.659774Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}