{"doi":"10.1007/s11938-015-0069-4","title":"Current Approach to the Management of Eosinophilic Esophagitis in Adults","abstract":null,"journal":"Current Treatment Options in Gastroenterology","year":2015,"id":616089,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233703,"name":"Walter W. Chan","orcid":"0000-0002-1709-8230","position":1,"is_corresponding":false},{"id":1588236,"name":"Alison H. Goldin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Current Approach to the Management of Eosinophilic Esophagitis in Adults","abstract":"<h4>Opinion statement</h4>Eosinophilic esophagitis (EoE) is an increasingly diagnosed, immune-mediated disease characterized by inflammation of the esophagus in both children and adult, causing significant morbidity. Adults typically present with dysphagia and a history of food impaction. Diagnosis should be considered in patients with histological evidence of eosinophilia (≥15 eosinophils per high-power field) on esophageal biopsy. More recently, it has been observed that a significant percentage of patients with esophageal eosinophilia respond both clinically and histologically to PPI therapy. This disorder has been named PPI-responsive esophageal eosinophilia (PPI-REE). Recent studies suggest that patients with PPI-REE have similar clinical and endoscopic features of patients with EoE. Specifically, both PPI-REE and EoE patients have a strong disposition to allergy compared to patients without eosinophilia. As such, PPI-REE may represent a subset or variant of EoE. Effective treatment of EoE requires a multidisciplinary approach with gastroenterologists, pathologists, allergists, and nutritionists. Treatments include elimination and elemental diets, topical glucocorticoids (fluticasone and budesonide), and endoscopic dilation.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26454851","pmcid":null,"openalex_id":"https://openalex.org/W1904059717","authors":[],"funders":[],"total_grants":0,"fwci":1.1372,"citation_percentile":0.77507326,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s11938-015-0069-4.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11938-015-0069-4/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s11938-015-0069-4","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11938-015-0069-4","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26454851","host_type":"repository"}],"fields_of_study":["Eosinophilic Esophagitis","Eosinophilic Disorders and Syndromes"],"mesh_terms":[],"keywords":["Eosinophilic esophagitis","Medicine","Eosinophilia","Dysphagia","High-power field","Gastroenterology","Internal medicine","GERD","Fluticasone","Esophagitis","Asthma","Disease","Radiology","Reflux","Topical Steroids","Endoscopic Dilation","Elimination Diet","Ppi-ree"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T21:55:04.404140Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}