{"doi":"10.1007/s11912-021-01114-x","title":"Cardiovascular Toxicity of Novel HER2-Targeted Therapies in the Treatment of Breast Cancer","abstract":null,"journal":"Current Oncology Reports","year":2021,"id":645347,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1680341,"name":"Amber Morse","orcid":null,"position":1,"is_corresponding":false},{"id":1680342,"name":"Sarah Burnette","orcid":null,"position":2,"is_corresponding":false},{"id":430237,"name":"Avirup Guha","orcid":"0000-0003-0253-1174","position":3,"is_corresponding":false},{"id":973904,"name":"Heather Moore","orcid":"0000-0002-2999-8332","position":4,"is_corresponding":false},{"id":1680339,"name":"Susan F. Dent","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cardiovascular Toxicity of Novel HER2-Targeted Therapies in the Treatment of Breast Cancer.","abstract":"<h4>Purpose of review</h4>HER2-targeted therapies have led to improved clinical outcomes in early and advanced breast cancer (BC). We review the long-term cardiotoxicity of HER2-targeted therapy in early and advanced BC, our current knowledge of cardiotoxicity of novel HER2-targeted therapies, and propose a cardiac monitoring (CM) strategy for this population.<h4>Recent findings</h4>Long-term data from studies with HER2-targeted therapy in the adjuvant setting have failed to demonstrate an increase in cardiotoxicity over time, and rates of cardiotoxicity seen with novel HER2 agents remain low. Despite over a decade of experience with HER2-targeted therapy, CM in clinical practice is inconsistent in patients with early BC and almost non-existent in advanced BC. Long-term follow-up of clinical trials with HER2-targeted agents in early and advanced BC has failed to demonstrate increased rates of cardiotoxicity over time, attesting to the long-term safety of this class of drugs for the majority of patients, although the long-term cardiac safety of newer HER2 agents in the non-clinical trial setting is largely unknown. We propose CM incorporating clinical history, cardiac imaging, and biomarkers.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34453232","pmcid":"PMC8395382","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s11912-021-01114-x.pdf","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8395382","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8395382","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8395382?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Humans","Breast Neoplasms","Antineoplastic Agents","Immunoconjugates","Protein Kinase Inhibitors","Female","Clinical Trials as Topic","Molecular Targeted Therapy","Cardiotoxicity","Erb-b2 Receptor Tyrosine Kinases"],"keywords":["Breast cancer","Cardiotoxicity","Cardiac Monitoring","Novel Her2 Agents"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T05:00:18.396284Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}