{"doi":"10.1007/s11910-013-0407-7","title":"Chronic Traumatic Encephalopathy: Where Are We and Where Are We Going?","abstract":null,"journal":"Current Neurology and Neuroscience Reports","year":2013,"id":637233,"datarank":0.7181237614173069,"base_score":4.787491742782046,"endowment":4.787491742782046,"self_citation_contribution":0.7181237614173069,"citation_network_contribution":0.0,"self_endowment_contribution":0.7181237614173069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":119,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":304496,"name":"Robert A. Stern","orcid":"0000-0002-5008-077X","position":1,"is_corresponding":false},{"id":271280,"name":"Ann C. McKee","orcid":"0000-0003-2961-7488","position":2,"is_corresponding":false},{"id":261843,"name":"Jesse Mez","orcid":"0000-0003-1438-5442","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chronic Traumatic Encephalopathy: Where Are We and Where Are We Going?","abstract":"Chronic traumatic encephalopathy (CTE, previously called punch drunk and dementia pugilistica) has a rich history in the medical literature in association with boxing, but has only recently been recognized with other contact sports, such as football and ice hockey, as well as with military blast injuries. CTE is thought to be a neurodegenerative disease associated with repeated concussive and subconcussive blows to the head. There is characteristic gross and microscopic pathology found in the brain, including frontal and temporal atrophy, axonal degeneration, and hyperphosphorylated tau and TAR DNA-binding protein 43 pathology. Clinically, there are characteristic progressive deficits in cognition (memory, executive dysfunction), behavior (explosivity, aggression), mood (depression, suicidality), and motor function (parkinsonism), which correlate with the anatomic distribution of brain pathology. While CTE shares clinical and neuropathological traits with other neurodegenerative diseases, the clinical syndrome and the neuropathology as a whole are distinct from other neurodegenerative diseases. Here we review the CTE literature to date. We also draw on the literature from mild traumatic brain injury and other neurodegenerative dementias, particularly when these studies provide guidance for future CTE research. We conclude by suggesting seven essential areas for future CTE research.","is_dataset_classified":null,"base_score":4.787491742782046,"endowment":4.787491742782046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24136455","pmcid":"PMC4550089","openalex_id":"https://openalex.org/W2043633971","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"5T32NS007153-27","title":"Neuroepidemiology Training Program"},{"funder_name":"NIA NIH HHS","grant_id":"P30 AG013846","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"T32 NS007153","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P30AG13846","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS078337","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01NS078337-02","title":"Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers"},{"funder_name":"National Institutes of Health","grant_id":"3P30AG013846-23S1","title":"Boston University Alzheimer's Disease Center"}],"total_grants":7,"fwci":7.9408,"citation_percentile":0.98146393,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":18},{"year":2016,"count":19},{"year":2017,"count":26},{"year":2018,"count":10},{"year":2019,"count":15},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":9},{"year":2023,"count":6},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550089","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550089","host_type":"repository"},{"url":"http://link.springer.com/content/pdf/10.1007/s11910-013-0407-7.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11910-013-0407-7/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s11910-013-0407-7","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11910-013-0407-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24136455","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc4550089?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1007/s11910-013-0407-7","host_type":""}],"fields_of_study":["Traumatic Brain Injury Research","Traumatic Brain Injury and Neurovascular Disturbances","Cardiac Arrest and Resuscitation","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Animals","Biomarkers","Boxing","Brain Injury, Chronic","Humans","Magnetic Resonance Imaging","Neuroimaging","Neuropsychological Tests","Positron-Emission Tomography","Tomography, Emission-Computed, Single-Photon","Tomography, X-Ray Computed"],"mesh_terms":["Animals","Boxing","Humans","Magnetic Resonance Imaging","Neuropsychological Tests","Tomography, X-Ray Computed","Biomarkers","Tomography, Emission-Computed, Single-Photon","Brain Injury, Chronic","Positron-Emission Tomography","Neuroimaging"],"keywords":["Chronic traumatic encephalopathy","Concussion","Traumatic brain injury","Tauopathy","Neuropathology","Parkinsonism","Medicine","Neuroscience","Dementia","Neurology","Depression (economics)","Atrophy","Corticobasal degeneration","Psychology","Pathology","Psychiatry","Poison control","Disease","Neurodegeneration","Injury prevention","Tomography, Emission-Computed, Single-Photon","Neuroimaging","Boxing","Neuropsychological Tests","Magnetic Resonance Imaging","Positron-Emission Tomography","Brain Injury, Chronic","Animals","Humans","Tomography, X-Ray Computed","Biomarkers"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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