{"doi":"10.1007/s11906-020-01048-y","title":"Relationship Between ACE2 and Other Components of the Renin-Angiotensin System","abstract":null,"journal":"Current Hypertension Reports","year":2020,"id":598363,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":913525,"name":"Thomas C. Hanff","orcid":"0000-0003-0270-2746","position":1,"is_corresponding":false},{"id":295963,"name":"Adam P. Bress","orcid":"0000-0002-2259-5039","position":2,"is_corresponding":false},{"id":284064,"name":"Andrew M. South","orcid":"0000-0002-3204-4142","position":3,"is_corresponding":false},{"id":228812,"name":"Jordana B. Cohen","orcid":"0000-0003-4649-079X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Relationship Between ACE2 and Other Components of the Renin-Angiotensin System","abstract":"PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32591908","pmcid":"PMC7317893","openalex_id":"https://openalex.org/W3038023608","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL007891","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"UC4 DK108173","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"L40 HL148910","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"K23 HL133843","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL146818","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"K01 HL133468","title":null},{"funder_name":"National Institutes of Health","grant_id":"1K23HL133843-01","title":"Management of hypertension in obesity: Antihypertensive class effects, blood pressure control, and renal and cardiac outcomes"},{"funder_name":"National Institutes of Health","grant_id":"1K01HL133468-01","title":"Genetic ancestry and antihypertensive medication responses in African Americans"},{"funder_name":"National Institutes of Health","grant_id":"1R01HL146818-01A1","title":"Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm"},{"funder_name":"National Institutes of Health","grant_id":"5T32HL007891-10","title":"Cardiology and Pulmonary Research Training Grant"},{"funder_name":"National Institutes of Health","grant_id":"3UC4DK108173-01S1","title":"Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study"}],"total_grants":11,"fwci":2.2032,"citation_percentile":0.89857967,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":6},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":6}],"oa_status":"hybrid","license":"other-oa","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s11906-020-01048-y.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s11906-020-01048-y.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11906-020-01048-y/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11906-020-01048-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32591908","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7317893","host_type":"repository"},{"url":"http://dx.doi.org/10.1007/s11906-020-01048-y","host_type":""},{"url":"https://dx.doi.org/10.1007/s11906-020-01048-y","host_type":""}],"fields_of_study":["Renin-Angiotensin System Studies","COVID-19 Clinical Research Studies","SARS-CoV-2 and COVID-19 Research","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Angiotensin-Converting Enzyme 2","Betacoronavirus","COVID-19","Coronavirus Infections","Humans","Pandemics","Peptidyl-Dipeptidase A","Pneumonia, Viral","Receptors, Virus","Renin-Angiotensin System","SARS-CoV-2"],"mesh_terms":["Betacoronavirus","Angiotensin-Converting Enzyme 2","COVID-19","SARS-CoV-2","Humans","Peptidyl-Dipeptidase A","Pneumonia, Viral","Receptors, Virus","Renin-Angiotensin System","Coronavirus Infections","Pandemics"],"keywords":["Renin–angiotensin system","Angiotensin-converting enzyme 2","Angiotensin II","Medicine","Coronavirus disease 2019 (COVID-19)","Proinflammatory cytokine","Angiotensin 1","Pathogenesis","Internal medicine","Pharmacology","Endocrinology","Disease","Receptor","Inflammation","Infectious disease (medical specialty)","Blood pressure","Hypertension","Cardiovascular disease","Angiotensin-converting enzyme inhibitors","angiotensin-converting enzyme","renin-angiotensin system","Chronic Kidney Disease","Angiotensin Receptor Blockers","Coronavirus Infections","Covid-19","SARS-CoV-2","Hot Topic","Pneumonia, Viral","Peptidyl-Dipeptidase A","Betacoronavirus","Humans","Receptors, Virus","Pandemics"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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