{"doi":"10.1007/s11886-017-0810-9","title":"Long-Term Use of Ticagrelor in Patients with Coronary Artery Disease","abstract":null,"journal":"Current Cardiology Reports","year":2017,"id":687660,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1599064,"name":"Giuseppe Gargiulo","orcid":"0000-0003-4395-6742","position":1,"is_corresponding":false},{"id":70455,"name":"Marco Valgimigli","orcid":"0000-0002-4353-7110","position":2,"is_corresponding":false},{"id":1796486,"name":"Sara Ariotti","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long-Term Use of Ticagrelor in Patients with Coronary Artery Disease","abstract":"<h4>Purpose of review</h4>This review aims to summarize and discuss safety and effectiveness of the long-term use of ticagrelor in patients with coronary artery disease (CAD).<h4>Recent findings</h4>Ticagrelor is an orally administered, direct, and reversible inhibitor of the P2Y<sub>12</sub>-platelet receptor. Long-term use of ticagrelor in patients with previous myocardial infarction (MI) has been investigated in the PEGASUS-TIMI-54 trial. Overall, 21,162 patients with a spontaneous MI 1 to 3 years before randomization were randomly assigned to ticagrelor 90 mg bid, ticagrelor 60 mg bid, or placebo. Compared with placebo, both doses of ticagrelor showed that they were capable of significantly reducing the primary efficacy endpoint, although with a significant increase in TIMI major bleeding. Intracranial hemorrhage or fatal bleeding did not differ across groups. These findings establish clear benefit of DAPT extension with ticagrelor beyond 1 year of treatment, which comes with a tradeoff of clinically meaningful bleeding. Altogether, current evidence suggests that the duration of DAPT remains a patient-by-patient decision based on thrombotic and bleeding risk profiles.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28097533","pmcid":null,"openalex_id":"https://openalex.org/W2578926377","authors":[],"funders":[],"total_grants":0,"fwci":0.6546,"citation_percentile":0.70641039,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s11886-017-0810-9.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11886-017-0810-9/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11886-017-0810-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28097533","host_type":"repository"}],"fields_of_study":["Antiplatelet Therapy and Cardiovascular Diseases","Acute Myocardial Infarction Research","Venous Thromboembolism Diagnosis and Management"],"mesh_terms":["Ticagrelor","Adenosine","Blood Platelets","Coronary Artery Disease","Hemorrhage","Humans","Myocardial Infarction","Thrombosis","Randomized Controlled Trials as Topic","Treatment Outcome","Purinergic P2Y Receptor Antagonists"],"keywords":["Ticagrelor","Medicine","TIMI","Coronary artery disease","Myocardial infarction","Internal medicine","P2Y12","Cardiology","Placebo","Platelet aggregation inhibitor","Clinical endpoint","Aspirin","Prasugrel","Acute coronary syndrome","Randomized controlled trial","Clopidogrel","Percutaneous coronary intervention","Antiplatelet Therapy","Ischemic Events","Bleeding Events","P2y12 Inhibitor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T22:26:01.511089Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}