{"doi":"10.1007/s11883-021-00965-w","title":"Lipid Phenotypes and DNA Methylation: a Review of the Literature","abstract":null,"journal":"Current Atherosclerosis Reports","year":2021,"id":596479,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":24975,"name":"Marguerite R. Irvin","orcid":"0000-0002-1442-2023","position":1,"is_corresponding":false},{"id":642461,"name":"Steven A. Claas","orcid":"0000-0001-9789-8395","position":2,"is_corresponding":false},{"id":24678,"name":"Donna K. Arnett","orcid":"0000-0003-2219-657X","position":3,"is_corresponding":false},{"id":1527657,"name":"Alana C. Jones","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lipid Phenotypes and DNA Methylation: a Review of the Literature","abstract":"<h4>Purpose of review</h4>Epigenetic modifications via DNA methylation have previously been linked to blood lipid levels, dyslipidemias, and atherosclerosis. The purpose of this review is to discuss current literature on the role of DNA methylation on lipid traits and their associated pathologies.<h4>Recent findings</h4>Candidate gene and epigenome-wide approaches have identified differential methylation of genes associated with lipid traits (particularly CPT1A, ABCG1, SREBF1), and novel approaches are being implemented to further characterize these relationships. Moreover, studies on environmental factors have shown that methylation variations at lipid-related genes are associated with diet and pollution exposure. Further investigation is needed to elucidate the directionality of the associations between the environment, lipid traits, and epigenome. Future studies should also seek to increase the diversity of cohorts, as European and Asian ancestry populations are the predominant study populations in the current literature.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34468868","pmcid":"PMC8956278","openalex_id":"https://openalex.org/W3198213140","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"T32 DK116672","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"F31 DK128990","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL091357","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R01HL091357-05","title":"Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat"},{"funder_name":"National Institutes of Health","grant_id":"3T32DK116672-02S1","title":"PRedoctoral Interdisciplinary training in renal physiology and MEdicine (PRIME)"}],"total_grants":5,"fwci":1.4063,"citation_percentile":0.81486972,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":10},{"year":2024,"count":3},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"green","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8956278","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956278","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8956278","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.1007/s11883-021-00965-w.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11883-021-00965-w/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11883-021-00965-w","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34468868","host_type":"repository"},{"url":"https://dx.doi.org/10.1007/s11883-021-00965-w","host_type":""}],"fields_of_study":["Epigenetics and DNA Methylation","Cancer-related gene regulation","RNA modifications and cancer","Medicine","Environmental Science","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","DNA Methylation","Dyslipidemias","Epigenesis, Genetic","Genome-Wide Association Study","Humans","Lipids","Phenotype"],"mesh_terms":["Humans","Lipids","Phenotype","DNA Methylation","Epigenesis, Genetic","Dyslipidemias","Genome-Wide Association Study"],"keywords":["Epigenome","Epigenetics","DNA methylation","Methylation","Biology","Genetics","Phenotype","Gene","Epigenomics","Bioinformatics","Computational biology","Gene expression","Lipids","Atherosclerosis","Dyslipidemia","Humans","Dyslipidemias","Epigenesis, Genetic","Genome-Wide Association Study"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T10:23:40.471313Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}