{"doi":"10.1007/s11764-024-01645-9","title":"Association of cancer treatment with excess heart age among five-year young breast cancer survivors","abstract":"PURPOSE: Data evaluating cardiovascular disease (CVD) risk by cancer treatment among young women (≤ 40 years) with breast cancer are limited. METHODS: Among 372 five-year breast cancer survivors aged 30-40 years from the Young Women's Breast Cancer Study, we assessed the association of cancer treatments (anthracyclines, trastuzumab, radiation/laterality, endocrine therapy) and excess heart age (difference between predicted 10-year CVD risk as assessed by adapted Framingham Risk Score and chronological age), prevalent elevated excess heart age (≥ 2 years), and worsening excess heart age (change of ≥ 2 excess heart age years) at breast cancer diagnosis and two- and five-year follow-up using multivariable linear and logistic regressions. RESULTS: Most women had stage I or II (79%), ER + (71%), or PR + (65%) breast cancer. At diagnosis, women had little excess heart age by treatment receipt (range of means = -0.52,0.91 years). Left-sided radiation (β = 2.49,SE = 0.96,p = 0.01) was associated with higher excess heart age at five-year follow-up. For prevalent elevated excess heart age (two-year = 26%;five-year = 27%), women treated with right-sided radiation had increased risk at two-years (OR = 2.17,95%CI = 1.12-4.19), yet at five-years, associations were observed after any radiation (OR = 1.92,95%CI = 1.09-3.41), especially after left-sided (OR = 2.13,95%CI = 1.09-3.41) radiation. No associations were observed between systemic treatments and prevalent elevated excess heart age or any treatments with worsening excess heart age. CONCLUSIONS: Among young breast cancer survivors, radiation, but not other cancer treatments, was associated with elevated excess heart age. IMPLICATIONS FOR CANCER SURVIVORS: CVD risk tools that incorporate cancer treatment, such as radiation, are needed to identify high risk young breast cancer survivors given the long survivorship and long latency of cardiovascular disease.","journal":"Journal of Cancer Survivorship","year":2024,"id":500944,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8084,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":378885,"name":"Shoshana M. 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Tamimi","orcid":"0000-0003-2306-8668","position":8,"is_corresponding":false},{"id":7931,"name":"Jeffrey Peppercorn","orcid":"0000-0001-7138-6404","position":9,"is_corresponding":false},{"id":948038,"name":"Lidia Schapira","orcid":"0000-0002-3298-9103","position":10,"is_corresponding":false},{"id":441767,"name":"Virginia F. Borges","orcid":"0000-0003-1158-7524","position":11,"is_corresponding":false},{"id":601062,"name":"Steven E. Come","orcid":"0000-0001-8136-2908","position":12,"is_corresponding":false},{"id":232168,"name":"Anju Nohria","orcid":"0000-0002-7113-1118","position":13,"is_corresponding":false},{"id":292886,"name":"Ann H. Partridge","orcid":"0000-0002-4722-4824","position":14,"is_corresponding":false},{"id":672906,"name":"Jacqueline B. 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