{"doi":"10.1007/s11604-024-01570-y","title":"CT findings as predictive factors for treatment failure in Mycobacterium abscessus complex lung disease: a retrospective cohort study","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Purpose</jats:title>\n                <jats:p><jats:italic>Mycobacterium abscessus</jats:italic> complex (MABC) commonly causes lung disease (LD) and has a high treatment failure rate of around 50%. In this study, our objective is to investigate specific CT patterns for predicting treatment prognosis and monitoring treatment response, thus providing valuable insights for clinical physicians in the management of MABC-LD treatment.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>We retrospectively assessed 34 patients with MABC-LD treated between January 2015 and December 2020. CT scores for bronchiectasis, cellular bronchiolitis, consolidation, cavities, and nodules were measured at initiation and after treatment. The ability of the CT scores to predict treatment outcomes was analyzed in logistic regression analyses.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>The CT scoring system had excellent inter-reader agreement (all intraclass correlation coefficients, &gt; 0.82). The treatment failure (TF) group (17/34; 50%) had higher cavitation diameter (<jats:italic>p</jats:italic> = 0.049) and extension (<jats:italic>p</jats:italic> = 0.041) at initial CT and higher cavitation diameter (<jats:italic>p</jats:italic> = 0.049) and extension (<jats:italic>p</jats:italic> =0 .045), consolidation (<jats:italic>p</jats:italic> = 0.022), and total (<jats:italic>p</jats:italic> = 0.013) scores at follow-up CT than the treatment success (TS) group. The changes of total score and consolidation score (<jats:italic>p</jats:italic> = 0.049 and 0.024, respectively) increased in the TF group more than the TS group between the initial and follow-up CT. Multivariable logistic regression analysis showed initial cavitation extension, follow-up consolidation extension, and change in consolidation extension (adjusted odds ratio: 2.512, 2.495, and 9.094, respectively, per 1-point increase; all <jats:italic>p</jats:italic> &lt; 0.05) were significant predictors of treatment failure.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusions</jats:title>\n                <jats:p>A high pre-treatment cavitation extension score and an increase in the consolidation extension score during treatment on CT could be alarm signs of treatment failure requiring tailor the treatment of MABC-LD carefully.</jats:p>\n              </jats:sec>","journal":"Japanese Journal of Radiology","year":2024,"id":634208,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644719,"name":"Yu-Sen Huang","orcid":"0000-0003-4262-8712","position":1,"is_corresponding":false},{"id":1644720,"name":"Yu-Cheng Huang","orcid":"0000-0003-0605-3085","position":2,"is_corresponding":false},{"id":1644722,"name":"Ming-Yann Lee","orcid":null,"position":3,"is_corresponding":false},{"id":1644723,"name":"Victor Jing-Wei Kang","orcid":"0000-0002-3797-5229","position":4,"is_corresponding":false},{"id":926986,"name":"Chin‐Chung Shu","orcid":"0000-0003-0311-5148","position":5,"is_corresponding":false},{"id":1507848,"name":"Yeun-Chung Chang","orcid":"0000-0001-9984-5713","position":6,"is_corresponding":false},{"id":1644718,"name":"Pin-Yi Chiang","orcid":"0000-0002-8701-8347","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CT findings as predictive factors for treatment failure in Mycobacterium abscessus complex lung disease: a retrospective cohort study","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Purpose</jats:title>\n                <jats:p><jats:italic>Mycobacterium abscessus</jats:italic> complex (MABC) commonly causes lung disease (LD) and has a high treatment failure rate of around 50%. In this study, our objective is to investigate specific CT patterns for predicting treatment prognosis and monitoring treatment response, thus providing valuable insights for clinical physicians in the management of MABC-LD treatment.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>We retrospectively assessed 34 patients with MABC-LD treated between January 2015 and December 2020. CT scores for bronchiectasis, cellular bronchiolitis, consolidation, cavities, and nodules were measured at initiation and after treatment. The ability of the CT scores to predict treatment outcomes was analyzed in logistic regression analyses.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>The CT scoring system had excellent inter-reader agreement (all intraclass correlation coefficients, &gt; 0.82). The treatment failure (TF) group (17/34; 50%) had higher cavitation diameter (<jats:italic>p</jats:italic> = 0.049) and extension (<jats:italic>p</jats:italic> = 0.041) at initial CT and higher cavitation diameter (<jats:italic>p</jats:italic> = 0.049) and extension (<jats:italic>p</jats:italic> =0 .045), consolidation (<jats:italic>p</jats:italic> = 0.022), and total (<jats:italic>p</jats:italic> = 0.013) scores at follow-up CT than the treatment success (TS) group. The changes of total score and consolidation score (<jats:italic>p</jats:italic> = 0.049 and 0.024, respectively) increased in the TF group more than the TS group between the initial and follow-up CT. Multivariable logistic regression analysis showed initial cavitation extension, follow-up consolidation extension, and change in consolidation extension (adjusted odds ratio: 2.512, 2.495, and 9.094, respectively, per 1-point increase; all <jats:italic>p</jats:italic> &lt; 0.05) were significant predictors of treatment failure.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusions</jats:title>\n                <jats:p>A high pre-treatment cavitation extension score and an increase in the consolidation extension score during treatment on CT could be alarm signs of treatment failure requiring tailor the treatment of MABC-LD carefully.</jats:p>\n              </jats:sec>","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38705936","pmcid":"PMC11286655","openalex_id":"https://openalex.org/W4396672686","authors":[],"funders":[{"funder_name":"National Taiwan University Hospital","grant_id":"111-N0059","title":null}],"total_grants":1,"fwci":0.5753,"citation_percentile":0.66296165,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s11604-024-01570-y.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s11604-024-01570-y.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11604-024-01570-y/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11604-024-01570-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38705936","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11286655","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11286655/pdf/11604_2024_Article_1570.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11286655","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11286655?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Mycobacterium research and diagnosis","Tuberculosis Research and Epidemiology","Diagnosis and treatment of tuberculosis","Humans","Retrospective Studies","Male","Female","Treatment Failure","Tomography, X-Ray Computed","Mycobacterium Infections, Nontuberculous","Middle Aged","Mycobacterium abscessus","Aged","Anti-Bacterial Agents","Lung Diseases","Predictive Value of Tests","Cohort Studies","Adult","Lung","Prognosis"],"mesh_terms":["Mycobacterium abscessus","Adult","Aged","Anti-Bacterial Agents","Female","Humans","Lung","Lung Diseases","Male","Middle Aged","Mycobacterium Infections, Nontuberculous","Predictive Value of Tests","Prognosis","Retrospective Studies","Tomography, X-Ray Computed","Cohort Studies","Treatment Failure"],"keywords":["Medicine","Logistic regression","Retrospective cohort study","Bronchiectasis","Internal medicine","Bronchiolitis","Odds ratio","Cohort","Lung","Surgery","Respiratory system","Thorax","Treatment outcome","computed tomography","Nontuberculous Mycobacteria","Mycobacterium Abscessus Complex Lung Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:18:58.187352Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}