{"doi":"10.1007/s11604-022-01370-2","title":"Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset","abstract":"PURPOSE: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is intended to reflect the glymphatic function of the brain; however, head rotation may reduce reproducibility and reliability. This study aimed to evaluate whether reorientation of DTI data improves the reproducibility of the ALPS index using the OASIS-3 dataset. MATERIALS AND METHODS: 234 cognitively normal subjects from the OASIS-3 dataset were included. Original and reoriented ALPS indices were calculated using a technique that registered vector information of DTI to another space and created reoriented diffusivity maps. The F test was used to compare variances of the original and reoriented ALPS indices. Subsequently, subjects with head rotation around the z- (inferior-superior; n = 43) or x axis (right-left; n = 25) and matched subjects with neutral head position were selected for evaluation of intra- and inter-rater reliability. Intraclass correlation coefficients (ICCs) of the original and reoriented ALPS indices for participants with head rotation and neutral head position were calculated separately. The Bland-Altman plot comparing the original and reoriented ALPS indices was also evaluated. RESULTS: The reoriented ALPS index exhibited a significantly smaller variance than the original ALPS index (p < 0.001). For intra- and inter-reliability, the reorientation technique showed good-to-excellent reproducibility in calculating the ALPS index even in subjects with head rotation (ICCs of original ALPS index: 0.52-0.81; ICCs of reoriented ALPS index: > 0.85). A wider range of the 95% limit of agreement of the Bland-Altman plot for subjects with x axis rotation was identified, indicating that x axis rotation may remarkably affect calculation of the ALPS index. CONCLUSION: The technique used in this study enabled the creation of reoriented diffusivity maps and improved reproducibility in calculating the ALPS index.","journal":"Japanese Journal of Radiology","year":2022,"id":237026,"datarank":2.5294050695987336,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":1.8964789138223173,"self_endowment_contribution":0.6329261557764161,"citer_contribution":1.8964789138223173,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":63,"citers_with_citation_signal":50,"citers_with_endowment":50,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9167,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":858633,"name":"Shu Matsushita","orcid":"0000-0003-1132-9736","position":1,"is_corresponding":false},{"id":59462,"name":"Daiju Ueda","orcid":"0000-0002-3878-3616","position":2,"is_corresponding":false},{"id":858634,"name":"Hirotaka Takita","orcid":"0000-0003-2860-4503","position":3,"is_corresponding":false},{"id":858635,"name":"Daisuke Horiuchi","orcid":"0000-0002-8929-8098","position":4,"is_corresponding":false},{"id":858636,"name":"Natsuko Atsukawa","orcid":"0009-0001-7170-1029","position":5,"is_corresponding":false},{"id":859574,"name":"Yuka Morishita","orcid":null,"position":6,"is_corresponding":false},{"id":207999,"name":"Taro Tsukamoto","orcid":null,"position":7,"is_corresponding":false},{"id":858637,"name":"Taro Shimono","orcid":"0000-0001-5847-6587","position":8,"is_corresponding":false},{"id":208000,"name":"Yukio Miki","orcid":"0000-0003-0621-0044","position":9,"is_corresponding":false},{"id":404819,"name":"Hiroyuki Tatekawa","orcid":"0000-0002-8050-4895","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:22:08.925400Z","pmid":"36472803","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}