{"doi":"10.1007/s11596-006-0614-4","title":"Relationsip between PTEN and VEGF expression and clinicopathological characteristics in HCC","abstract":null,"journal":"Journal of Huazhong University of Science and Technology","year":2006,"id":656351,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1713360,"name":"Jilin Yi","orcid":null,"position":1,"is_corresponding":false},{"id":1486127,"name":"Enyu Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1713361,"name":"Xingrui Li","orcid":null,"position":3,"is_corresponding":false},{"id":1713359,"name":"Denghai Mi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Relationsip between PTEN and VEGF expression and clinicopathological characteristics in HCC","abstract":"To investigate the expressions and significance of the tumor suppressor gene phosphatase and tensin homolog deleted on chromosome ten protein (PTEN) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC), and to analyze the relationship between their expressions and the tumor's invasion and their peri-carcinomatous tissues, the correlation of their expressions with the tumor's clinicopathological characteristics and invasion potential were studied. Our study showed that the expression level of PTEN in HCC was remarkably lower than that in peri-carcinomatous liver tissues, while the expressions of both VEGF and MVD were higher than that in peri-carcinomatous liver tissues. Correlation analysis revealed that the expression of PTEN was negatively related to the progression of the pathological differentiation and invasion of tumor, whereas the expressions of VEGF and MVD were positively related. Moreover, there was a negative relationship between the expression of PTEN and the expressions of VEGF and MVD, and a positive one between VEGF and MVD. The expressions of PTEN and VEGF may reveal the degree of differentiation and the invasive potential of HCC tissues. The mechanism by which the lack of PTEN expression probably induces abnormal hyperexpression of VEGF may play an important role in the invasion and metastasis of HCC.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17357488","pmcid":null,"openalex_id":"https://openalex.org/W1987268729","authors":[],"funders":[],"total_grants":0,"fwci":0.2542,"citation_percentile":0.53834838,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2022,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s11596-006-0614-4.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11596-006-0614-4/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s11596-006-0614-4","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11596-006-0614-4","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17357488","host_type":"repository"}],"fields_of_study":["PI3K/AKT/mTOR signaling in cancer","Cancer, Hypoxia, and Metabolism","Hepatocellular Carcinoma Treatment and Prognosis"],"mesh_terms":["Adult","Aged","Female","Carcinoma, Hepatocellular","Humans","Liver Neoplasms","Male","Middle Aged","Vascular Endothelial Growth Factor A","PTEN Phosphohydrolase","Young Adult"],"keywords":["PTEN","Tensin","Hepatocellular carcinoma","Vascular endothelial growth factor","Cancer research","Metastasis","Biology","Pathology","Phosphatase","Pathological","Tumor suppressor gene","CYR61","VEGF receptors","Cancer","Medicine","Growth factor","Carcinogenesis","Signal transduction","Phosphorylation","PI3K/AKT/mTOR pathway","Cell biology","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T20:35:29.244817Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}