{"doi":"10.1007/s11481-013-9447-7","title":"Up-Regulation of Neurotrophic Factors by Cinnamon and its Metabolite Sodium Benzoate: Therapeutic Implications for Neurodegenerative Disorders","abstract":null,"journal":"Journal of Neuroimmune Pharmacology","year":2013,"id":621031,"datarank":0.7289718606542509,"base_score":4.859812404361672,"endowment":4.859812404361672,"self_citation_contribution":0.7289718606542509,"citation_network_contribution":0.0,"self_endowment_contribution":0.7289718606542509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":128,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":332721,"name":"Khushbu K. Modi","orcid":null,"position":1,"is_corresponding":false},{"id":330593,"name":"Avik Roy","orcid":"0000-0003-0523-8504","position":2,"is_corresponding":false},{"id":1603440,"name":"John A. Anderson","orcid":null,"position":3,"is_corresponding":false},{"id":402449,"name":"Richard B. van Breemen","orcid":"0000-0003-2016-0063","position":4,"is_corresponding":false},{"id":330597,"name":"Kalipada Pahan","orcid":"0000-0001-6048-9598","position":5,"is_corresponding":false},{"id":238624,"name":"Arundhati Jana","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Up-Regulation of Neurotrophic Factors by Cinnamon and its Metabolite Sodium Benzoate: Therapeutic Implications for Neurodegenerative Disorders","abstract":"This study underlines the importance of cinnamon, a widely-used food spice and flavoring material, and its metabolite sodium benzoate (NaB), a widely-used food preservative and a FDA-approved drug against urea cycle disorders in humans, in increasing the levels of neurotrophic factors [e.g., brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3)] in the CNS. NaB, but not sodium formate (NaFO), dose-dependently induced the expression of BDNF and NT-3 in primary human neurons and astrocytes. Interestingly, oral administration of ground cinnamon increased the level of NaB in serum and brain and upregulated the levels of these neurotrophic factors in vivo in mouse CNS. Accordingly, oral feeding of NaB, but not NaFO, also increased the level of these neurotrophic factors in vivo in the CNS of mice. NaB induced the activation of protein kinase A (PKA), but not protein kinase C (PKC), and H-89, an inhibitor of PKA, abrogated NaB-induced increase in neurotrophic factors. Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-κB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB. Accordingly, cinnamon feeding also increased the activity of PKA and the level of phospho-CREB in vivo in the CNS. These results highlight a novel neutrophic property of cinnamon and its metabolite NaB via PKA - CREB pathway, which may be of benefit for various neurodegenerative disorders.","is_dataset_classified":null,"base_score":4.859812404361672,"endowment":4.859812404361672,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23475543","pmcid":"PMC3663914","openalex_id":"https://openalex.org/W1993213120","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R21 NS064564","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R21 NS071479","title":null},{"funder_name":"NCCIH NIH HHS","grant_id":"AT6681","title":null},{"funder_name":"NCCIH NIH HHS","grant_id":"R01 AT006681","title":null}],"total_grants":4,"fwci":2.4667,"citation_percentile":0.8855472,"influential_citations":0,"citation_trend":[{"year":2014,"count":7},{"year":2015,"count":8},{"year":2016,"count":4},{"year":2017,"count":14},{"year":2018,"count":10},{"year":2019,"count":14},{"year":2020,"count":10},{"year":2021,"count":16},{"year":2022,"count":10},{"year":2023,"count":14},{"year":2024,"count":11},{"year":2025,"count":6},{"year":2026,"count":4}],"oa_status":"green","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3663914","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3663914","host_type":"repository"},{"url":"http://link.springer.com/content/pdf/10.1007/s11481-013-9447-7.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11481-013-9447-7/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s11481-013-9447-7","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11481-013-9447-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23475543","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3663914","host_type":"repository"}],"fields_of_study":["Nerve injury and regeneration","Neurogenesis and neuroplasticity mechanisms","Pancreatic function and diabetes","Animals","Cells, Cultured","Cinnamomum zeylanicum","Fetus","Humans","Mice","Mice, Inbred C57BL","Nerve Growth Factors","Neurodegenerative Diseases","Plant Extracts","Sodium Benzoate","Up-Regulation"],"mesh_terms":["Animals","Cells, Cultured","Cinnamomum zeylanicum","Fetus","Humans","Mice, Inbred C57BL","Nerve Growth Factors","Plant Extracts","Up-Regulation","Neurodegenerative Diseases","Sodium Benzoate","Mice"],"keywords":["CREB","Neurotrophic factors","Neurotrophin","Brain-derived neurotrophic factor","Pharmacology","Protein kinase A","Chemistry","Endocrinology","Internal medicine","Biology","Biochemistry","Medicine","Transcription factor","Kinase","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T12:58:31.701813Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}