{"doi":"10.1007/s11357-021-00331-3","title":"Alterations in the estrogen receptor profile of cardiovascular tissues during aging","abstract":null,"journal":"GeroScience","year":2021,"id":678075,"datarank":0.5837730447165941,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.0,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1771668,"name":"Isabella M. Kilanowski-Doroh","orcid":null,"position":1,"is_corresponding":false},{"id":1771669,"name":"Dillion D. Hutson","orcid":null,"position":2,"is_corresponding":false},{"id":688428,"name":"Benard O. Ogola","orcid":"0000-0002-6084-6986","position":3,"is_corresponding":false},{"id":688889,"name":"Margaret A. Zimmerman","orcid":null,"position":4,"is_corresponding":false},{"id":273764,"name":"Prasad V. G. Katakam","orcid":"0000-0002-4708-9140","position":5,"is_corresponding":false},{"id":949893,"name":"Ryousuke Satou","orcid":"0000-0001-6505-9722","position":6,"is_corresponding":false},{"id":703971,"name":"Ricardo Mostany","orcid":"0000-0002-5379-0080","position":7,"is_corresponding":false},{"id":411982,"name":"Sarah H. Lindsey","orcid":"0000-0002-9837-4582","position":8,"is_corresponding":false},{"id":710965,"name":"Rakesh Gurrala","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Alterations in the estrogen receptor profile of cardiovascular tissues during aging","abstract":"Estrogen exerts protective effects on the cardiovascular system via three known estrogen receptors: alpha (ERα), beta (ERß), and the G protein-coupled estrogen receptor (GPER). Our laboratory has previously showed the importance of GPER in the beneficial cardiovascular effects of estrogen. Since clinical studies indicate that the protective effects of exogenous estrogen on cardiovascular function are attenuated or reversed 10 years post-menopause, the hypothesis was that GPER expression may be reduced during aging. Vascular reactivity and GPER protein expression were assessed in female mice of varying ages. Physiological parameters, blood pressure, and estrogen receptor transcripts via droplet digital PCR (ddPCR) were assessed in the heart, kidney, and aorta of adult, middle-aged, and aged male and female C57BL/6 mice. Vasodilation to estrogen (E2) and the GPER agonist G-1 were reduced in aging female mice and were accompanied by downregulation of GPER protein. However, ERα and GPER were the predominant receptors in all tissues, whereas ERß was detectable only in the kidney. Female sex was associated with higher mRNA for both ERα and GPER in both the aorta and the heart. Aging impacted receptor transcript in a tissue-dependent manner. ERα transcript decreased in the heart with aging, while GPER expression increased in the heart. These data indicate that aging impacts estrogen receptor expression in the cardiovascular system in a tissue- and sex-specific manner. Understanding the impact of aging on estrogen receptor expression is critical for developing selective hormone therapies that protect from cardiovascular damage.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33558965","pmcid":"PMC8050209","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Heart, Lung, and Blood Institute","grant_id":"HL133619","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"P30GM103337","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"U54GM104940","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"DK107694","title":null},{"funder_name":"National Institute of Neurological Disorders and Stroke","grant_id":"NS094834","title":null},{"funder_name":"National Institute on Aging","grant_id":"AG047296","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS094834","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL133619","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG047296","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK107694","title":null},{"funder_name":"National Institutes of Health","grant_id":"3U54GM104940-07S3","title":"Louisiana Clinical and Translational Science Center Supplement - COVID Sequence Surveillance Network"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG047296-05","title":"Cortical Synaptic Dynamics during Learning  in the Aging Brain"},{"funder_name":"National Institutes of Health","grant_id":"4P30GM103337-05","title":"Translational Research in Hypertension and Renal Biology"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS094834-04","title":"Endothelial Expression of Neuronal Nitric Oxide Synthase"},{"funder_name":"National Institutes of Health","grant_id":"1R01DK107694-01","title":"Histone deacetylase 9 is an epigenetic suppressor of intrarenal angiotensinogen, serving as a key mechanism in angiotensinogen augmentation in hypertension"}],"total_grants":15,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"Springer TDM","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s11357-021-00331-3.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11357-021-00331-3/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11357-021-00331-3","host_type":""},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050209","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/33558965","host_type":""},{"url":"https://dx.doi.org/10.1007/s11357-021-00331-3","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Cardiovascular System","Animals","Mice, Inbred C57BL","Mice","Receptors, Estrogen","Estrogens","Aging","Female","Male"],"keywords":["Aging","Aromatase","Estrogen receptors","Sex differences","cardiovascular","Droplet Digital Pcr (Ddpcr)","Male","Mice, Inbred C57BL","Mice","Receptors, Estrogen","Animals","Estrogens","Female","Cardiovascular System"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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