{"doi":"10.1007/s11356-022-24253-5","title":"Immunoprotective role of aloin and disease resistance in Labeo rohita, infected with bacterial fish pathogen, Aeromonas hydrophila","abstract":null,"journal":"Environmental Science and Pollution Research","year":2022,"id":683564,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1785726,"name":"Usha Kumari","orcid":null,"position":1,"is_corresponding":false},{"id":1785727,"name":"Swati Mittal","orcid":null,"position":2,"is_corresponding":false},{"id":1785728,"name":"Ajay Kumar Mittal","orcid":null,"position":3,"is_corresponding":false},{"id":1785725,"name":"Ayan Srivastava","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immunoprotective role of aloin and disease resistance in Labeo rohita, infected with bacterial fish pathogen, Aeromonas hydrophila","abstract":"The effect of aloin on mucosal immune response and disease resistance was elucidated in Labeo rohita infected with the bacterial fish pathogen, Aeromonas hydrophila. Fishes were divided into four groups: (i) control, (ii) vehicle control, (iii) bacteria infected and (iv) bacteria infected and aloin treated. Fish were intraperitoneally injected with A. hydrophila suspension at the dose of 2 × 10<sup>6</sup> CFU/fish at 0 day (d). Following bacterial injection at 0 d, fish were treated with aloin at a dose of 1 mg/kg body weight intraperitoneally at an interval of 24 h for 4 consecutive days. Mucus collected from fish of each group was analyzed at 2 d, 4 d, 6 d, 8 d and 10 d. In bacteria-infected fish, a significant decrease (P < 0.05) in the activity of certain enzymatic and non-enzymatic immune parameters was observed. The activity of these immune parameters showed a gradual recovery on administration of aloin in bacteria-infected fish. Cumulative mortality was also found to be low in the aloin-treated group as compared to that in the infected group. Thus, aloin could act as an immunostimulant and play a protective role against disease caused by bacteria.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36427124","pmcid":null,"openalex_id":"https://openalex.org/W4310079751","authors":[],"funders":[{"funder_name":"University Grants Commission","grant_id":"UGC–UPE/FA–II/2018/19","title":null},{"funder_name":"University Grants Commission","grant_id":"CAS","title":null},{"funder_name":"Department of Science & Technology","grant_id":"FIST","title":null},{"funder_name":"University Grants Commission","grant_id":"UGC-UPE/FA-II/2018/19","title":null}],"total_grants":4,"fwci":0.7538,"citation_percentile":0.67597281,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":6}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s11356-022-24253-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11356-022-24253-5/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11356-022-24253-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36427124","host_type":"repository"}],"fields_of_study":["Aquaculture disease management and microbiota","Aquaculture Nutrition and Growth","Invertebrate Immune Response Mechanisms","Animals","Disease Resistance","Aeromonas hydrophila","Gram-Negative Bacterial Infections","Cyprinidae","Fish Diseases","Emodin"],"mesh_terms":["Animals","Cyprinidae","Emodin","Fish Diseases","Gram-Negative Bacterial Infections","Aeromonas hydrophila","Disease Resistance"],"keywords":["Aeromonas hydrophila","Labeo","Microbiology","Pathogen","Biology","Immunostimulant","Bacteria","Aeromonas","Immune system","Mucus","Immunology","Fish <Actinopterygii>","Fishery","Ecology","Disease resistance","aloin","Immune Parameters","Labeo Rohita"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T11:31:20.640663Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}