{"doi":"10.1007/s11306-024-02130-1","title":"Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda","abstract":"Abstract Introduction Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma associated with Plasmodium falciparum and Epstein-Barr virus, both of which affect metabolic pathways. The metabolomic patterns of BL is unknown. Materials and methods We measured 627 metabolites in pre-chemotherapy treatment plasma samples from 25 male children (6–11 years) with BL and 25 cancer-free area- and age-frequency-matched male controls from the Epidemiology of Burkitt Lymphoma in East African Children and Minors study in Uganda using liquid chromatography-tandem mass spectrometry. Unconditional, age-adjusted logistic regression analysis was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for the BL association with 1-standard deviation increase in the log-metabolite concentration, adjusting for multiple comparisons using false discovery rate (FDR) thresholds and Bonferroni correction. Results Compared to controls, levels for 42 metabolite concentrations differed in BL cases (FDR < 0.001), including triacylglyceride (18:0_38:6), alpha-aminobutyric acid (AABA), ceramide (d18:1/20:0), phosphatidylcholine ae C40:6 and phosphatidylcholine C38:6 as the top signals associated with BL (ORs = 6.9 to 14.7, P < 2.4✕10 − 4 ). Two metabolites (triacylglyceride (18:0_38:6) and AABA) selected using stepwise logistic regression discriminated BL cases from controls with an area under the curve of 0.97 (95% CI: 0.94, 1.00). Conclusion Our findings warrant further examination of plasma metabolites as potential biomarkers for BL risk/diagnosis.","journal":"Metabolomics","year":2024,"id":500018,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5856,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513900,"name":"Hadijah Nabalende","orcid":null,"position":1,"is_corresponding":false},{"id":226947,"name":"M. Constanza Camargo","orcid":"0000-0002-1065-2198","position":2,"is_corresponding":false},{"id":293402,"name":"Jacqueline Lovett","orcid":null,"position":3,"is_corresponding":false},{"id":486412,"name":"Isaac Otim","orcid":"0000-0001-8000-9483","position":4,"is_corresponding":false},{"id":486413,"name":"Ismail D. Legason","orcid":"0000-0002-6118-542X","position":5,"is_corresponding":false},{"id":513901,"name":"Martin D. Ogwang","orcid":null,"position":6,"is_corresponding":false},{"id":487522,"name":"Patrick Kerchan","orcid":null,"position":7,"is_corresponding":false},{"id":513902,"name":"Tobias Kinyera","orcid":null,"position":8,"is_corresponding":false},{"id":486414,"name":"Leona W. Ayers","orcid":"0000-0002-7261-260X","position":9,"is_corresponding":false},{"id":486415,"name":"Kishor Bhatia","orcid":"0000-0002-5319-7957","position":10,"is_corresponding":false},{"id":24059,"name":"James J. Goedert","orcid":"0000-0001-6134-1472","position":11,"is_corresponding":false},{"id":301539,"name":"Steven J. Reynolds","orcid":"0000-0002-5403-2759","position":12,"is_corresponding":false},{"id":260447,"name":"Peter D. Crompton","orcid":"0000-0001-5629-0412","position":13,"is_corresponding":false},{"id":348016,"name":"Steven C. Moore","orcid":"0000-0002-8169-1661","position":14,"is_corresponding":false},{"id":291303,"name":"Ruin Moaddel","orcid":"0000-0002-6812-0127","position":15,"is_corresponding":false},{"id":218606,"name":"Demetrius Albanes","orcid":"0000-0001-8330-4293","position":16,"is_corresponding":false},{"id":304255,"name":"Sam M. Mbulaiteye","orcid":"0000-0002-8273-9831","position":17,"is_corresponding":false},{"id":1349104,"name":"Jiaqi Huang","orcid":"0000-0002-9662-0399","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:10:04.829419Z","pmid":"38940866","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}