{"doi":"10.1007/s11154-008-9092-2","title":"Adrenal changes associated with adrenarche","abstract":null,"journal":"Reviews in Endocrine and Metabolic Disorders","year":2009,"id":604708,"datarank":2.56683372757726,"base_score":4.430816798843313,"endowment":4.430816798843313,"self_citation_contribution":0.6646225198264971,"citation_network_contribution":1.9022112077507631,"self_endowment_contribution":0.6646225198264971,"citer_contribution":1.9022112077507631,"corpus_percentile":null,"corpus_rank":null,"citation_count":83,"citer_count":68,"citers_with_citation_signal":55,"citers_with_endowment":55,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551608,"name":"Hui Xiao Gang","orcid":null,"position":1,"is_corresponding":false},{"id":772322,"name":"Takashi Suzuki","orcid":"0000-0001-7396-348X","position":2,"is_corresponding":false},{"id":307970,"name":"Hironobu Sasano","orcid":"0000-0002-6600-8641","position":3,"is_corresponding":false},{"id":307968,"name":"William E. Rainey","orcid":"0000-0001-5557-8406","position":4,"is_corresponding":false},{"id":172851,"name":"Yasuhiro Nakamura","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Adrenal changes associated with adrenarche","abstract":"The mechanisms causing the rise in adrenal androgen production during the course of adrenarche remain to be defined. However, the increase in steroid release is clearly associated with a series of intra-adrenal changes in the expression of steroidogenic enzymes needed for dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) production, as well as an expansion of the adrenal zona reticularis (ZR). We and others have defined the adrenal expression pattern of key steroidogenic enzymes during adrenarche. As adrenarche proceeds, the expanding ZR expresses greater levels of cytochrome b5 (CYB5) and steroid sulfotransferase (SULT2A1) than the adjacent fasciculata. In contrast, the growing ZR is deficient in 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2). The resulting profile of steroidogenic enzymes lends itself to the production of adrenal androgens and appears to track the progression of adrenarche. This article reviews the intra-adrenal changes of the adrenal cortex associated with adrenarche.","is_dataset_classified":null,"base_score":4.430816798843313,"endowment":4.430816798843313,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18821019","pmcid":"PMC3712864","openalex_id":"https://openalex.org/W1979060893","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK069950","title":null}],"total_grants":1,"fwci":2.5627,"citation_percentile":0.89739016,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":5},{"year":2014,"count":6},{"year":2015,"count":3},{"year":2016,"count":9},{"year":2017,"count":4},{"year":2018,"count":6},{"year":2019,"count":2},{"year":2020,"count":6},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":6},{"year":2024,"count":1},{"year":2026,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s11154-008-9092-2.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11154-008-9092-2/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s11154-008-9092-2","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11154-008-9092-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18821019","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3712864","host_type":"repository"}],"fields_of_study":["Hormonal and reproductive studies","Hypothalamic control of reproductive hormones","Estrogen and related hormone effects","17-Hydroxysteroid Dehydrogenases","3-Hydroxysteroid Dehydrogenases","Adrenal Cortex","Adrenal Glands","Adrenarche","Aldo-Keto Reductase Family 1 Member C3","Animals","Child","Cholesterol Side-Chain Cleavage Enzyme","Cytochromes b5","Hominidae","Humans","Hydroxyprostaglandin Dehydrogenases","Progesterone Reductase","Steroid 17-alpha-Hydroxylase","Steroid 21-Hydroxylase","Sulfotransferases"],"mesh_terms":["Aldo-Keto Reductase Family 1 Member C3","Adrenal Cortex","Adrenal Glands","Animals","Child","Cholesterol Side-Chain Cleavage Enzyme","Humans","Hydroxyprostaglandin Dehydrogenases","Progesterone Reductase","Steroid 17-alpha-Hydroxylase","Steroid 21-Hydroxylase","17-Hydroxysteroid Dehydrogenases","3-Hydroxysteroid Dehydrogenases","Hominidae","Sulfotransferases","Cytochromes b5","Adrenarche"],"keywords":["Adrenarche","Zona reticularis","Endocrinology","Adrenal cortex","Dehydroepiandrosterone","Internal medicine","Dehydroepiandrosterone sulfate","Zona fasciculata","Androgen","Adrenal disorder","Chemistry","Zona glomerulosa","Biology","Medicine","Hormone"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:45:55.178732Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}