{"doi":"10.1007/s11065-015-9281-1","title":"Genetics and Brain Morphology","abstract":null,"journal":"Neuropsychology Review","year":2015,"id":596830,"datarank":0.6064576901751826,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":0.0,"self_endowment_contribution":0.6064576901751826,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1362126,"name":"Baptiste Couvy-Duchesne","orcid":null,"position":1,"is_corresponding":false},{"id":107811,"name":"Narelle K. Hansell","orcid":"0000-0002-8229-9741","position":2,"is_corresponding":false},{"id":79779,"name":"Gabriel Cuellar-Partida","orcid":null,"position":3,"is_corresponding":false},{"id":5254,"name":"Sarah E. Medland","orcid":"0000-0003-1382-380X","position":4,"is_corresponding":false},{"id":109341,"name":"Margaret J. Wright","orcid":"0000-0001-7133-4970","position":5,"is_corresponding":false},{"id":107772,"name":"Lachlan T. Strike","orcid":"0000-0003-2885-5898","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genetics and Brain Morphology","abstract":"A wealth of empirical evidence is accumulating on the genetic mediation of brain structure phenotypes. This comes from twin studies that assess heritability and genetic covariance between traits, candidate gene associations, and genome-wide association studies (GWAS) that can identify specific genetic variants. Here we review the major findings from each of these approaches and consider how they inform on the genetic architecture of brain structure. The findings from twin studies show there is a strong genetic influence (heritability) on brain structure, and overlap of genetic effects (pleiotropy) between structures, and between structure and cognition. However, there is also evidence for genetic specificity, with distinct genetic effects across some brain regions. Candidate gene associations show little convergence; most have been under powered to detect effect sizes of the magnitude now expected. GWAS have identified 19 genetic variants for brain structure, though no replicated associations account for more than 1% of the variance. Together these studies are revealing new insights into the genetic architecture of brain morphology. As the scope of inquiry broadens, including measures that capture the complexity of the brain, along with larger samples and new analyses, such as genome-wide common trait analysis (GCTA) and polygenic scores, which combine variant effects for a phenotype, as well as whole-genome sequencing, more genetic variants for brain structure will be identified. Increasingly, large-scale multi-site studies will facilitate this next wave of studies, and promise to enhance our understanding of the etiology of variation in brain morphology, as well as brain disorders.","is_dataset_classified":null,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25773500","pmcid":null,"openalex_id":"https://openalex.org/W1986483120","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD050735","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1009064","title":"Genetics of brain structure and function"},{"funder_name":"National Institutes of Health","grant_id":"5R01HD050735-02","title":"Genetic influences on the brain: A twin imaging study"}],"total_grants":4,"fwci":8.5513,"citation_percentile":0.98080353,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":5},{"year":2017,"count":7},{"year":2018,"count":25},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s11065-015-9281-1.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s11065-015-9281-1/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s11065-015-9281-1","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11065-015-9281-1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25773500","host_type":"repository"},{"url":"https://api.library.uq.edu.au/view/UQ:354549","host_type":""},{"url":"https://espace.library.uq.edu.au/view/UQ:354549","host_type":""},{"url":"https://dx.doi.org/10.1007/s11065-015-9281-1","host_type":""},{"url":"https://doi.org/https://doi.org/10.1007/s11065-015-9281-1","host_type":""}],"fields_of_study":["Genetic Associations and Epidemiology","Genetic Mapping and Diversity in Plants and Animals","Genomic variations and chromosomal abnormalities","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Brain","Cognition","Genetic Variation","Genome-Wide Association Study","Humans","Neuroimaging","Phenotype","Twin Studies as Topic"],"mesh_terms":["Brain","Cognition","Humans","Phenotype","Genetic Variation","Twin Studies as Topic","Genome-Wide Association Study","Neuroimaging"],"keywords":["Brain morphometry","Morphology (biology)","Psychology","Imaging genetics","Neuropsychology","Evolutionary biology","Neuroimaging","Neuroscience","Genetics","Biology","Cognition","Medicine","Magnetic resonance imaging","Twins","Brain","Genetic Variation","3206 Neuropsychology and Physiological Psychology","Phenotype","Genes","616","Humans","Twin Studies as Topic","Genome-Wide Association Study"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. Zero hunger"},{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:26:50.660061Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}