{"doi":"10.1007/s11064-020-03049-4","title":"Capsaicin and Its Analogues Impede Nocifensive Response of Caenorhabditis elegans to Noxious Heat","abstract":null,"journal":"Neurochemical Research","year":2020,"id":616599,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1589814,"name":"Jennifer Ben Salem","orcid":null,"position":1,"is_corresponding":false},{"id":1333898,"name":"Francis Beaudry","orcid":"0000-0001-5403-7333","position":2,"is_corresponding":false},{"id":1589813,"name":"Bruno Nkambeu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Capsaicin and Its Analogues Impede Nocifensive Response of Caenorhabditis elegans to Noxious Heat","abstract":"Capsaicin is the most abundant pungent molecule identified in red chili peppers, and it is widely used for food flavoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several other related vanilloid compounds are secondary plant metabolites. Capsaicin is a selective agonist of the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1). After exposition to vanilloid solution, Caenorhabditis elegans wild type (N2) and mutants were placed on petri dishes divided in quadrants for heat stimulation. Thermal avoidance index was used to phenotype each tested C. elegans experimental groups. The data revealed for the first-time that capsaicin can impede nocifensive response of C. elegans to noxious heat (32-35 °C) following a sustained exposition. The effect was reversed 6 h post capsaicin exposition. Additionally, we identified the capsaicin target, the C. elegans transient receptor potential channel OCR-2 and not OSM-9. Further experiments also undoubtedly revealed anti-nociceptive effect for capsaicin analogues, including olvanil, gingerol, shogaol and curcumin.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32418082","pmcid":null,"openalex_id":"https://openalex.org/W3024106091","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"RGPIN-2015-05071","title":null},{"funder_name":"Canada Foundation for Innovation","grant_id":"36706","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":1.1423,"citation_percentile":0.73712183,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":8},{"year":2026,"count":4}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s11064-020-03049-4.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11064-020-03049-4/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11064-020-03049-4","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32418082","host_type":"repository"},{"url":"http://hdl.handle.net/1866/23368","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/23/2020.01.21.914010.full.pdf","host_type":""},{"url":"https://doi.org/10.1101/2020.01.21.914010","host_type":""},{"url":"https://dx.doi.org/10.1101/2020.01.21.914010","host_type":""},{"url":"https://dx.doi.org/10.1007/s11064-020-03049-4","host_type":""},{"url":"https://hdl.handle.net/1866/23368","host_type":""},{"url":"http://dx.doi.org/10.1101/2020.01.21.914010","host_type":""}],"fields_of_study":["Circadian rhythm and melatonin","Ion Channels and Receptors","Genetics, Aging, and Longevity in Model Organisms","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Taxis Response","Analgesics","Animals","Capsaicin","Hot Temperature","Nerve Tissue Proteins","Caenorhabditis elegans","Caenorhabditis elegans Proteins","TRPV Cation Channels"],"keywords":["Capsaicin","TRPV1","Transient receptor potential channel","Chemistry","Resiniferatoxin","Pharmacology","Noxious stimulus","Gingerol","TRPV","Nociception","Stimulation","Receptor","Biochemistry","Biology","Neuroscience","Food science","Caenorhabditis elegans","Transient Receptor Potential Cation Channel","Capsaicin Analogs","Analgesics","Hot Temperature","TRPV Cation Channels","Nerve Tissue Proteins","Animals","Taxis Response","Caenorhabditis elegans Proteins"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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