{"doi":"10.1007/s11060-024-04613-6","title":"Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors","abstract":"PURPOSE: Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institutional format. We hypothesized that this expansion would allow expert review of challenging neuro-oncology cases and contribute to the care of patients with limited access to specialized centers. METHODS: We retrospectively reviewed records from virtual MTBs held between 04/2020-03/2021. Data collected included measures of potential clinical impact, including referrals to observational or therapeutic studies, referrals for specialized neuropathology analysis, and whether molecular findings led to a change in diagnosis and/or guided management suggestions. RESULTS: During 25 meetings, 32 presenters discussed 44 cases. Approximately half (n = 20; 48%) involved a rare central nervous system (CNS) tumor. In 21% (n = 9) the diagnosis was changed or refined based on molecular profiling obtained at the NIH and in 36% (n = 15) molecular findings guided management. Clinical trial suggestions were offered to 31% (n = 13), enrollment in the observational NCI Natural History Study to 21% (n = 9), neuropathology review and molecular testing at the NIH to 17% (n = 7), and all received management suggestions. CONCLUSION: Virtual multi-institutional MTBs enable remote expert review of CNS tumors. We propose them as a strategy to facilitate expert opinions from specialized centers, especially for rare CNS tumors, helping mitigate geographic barriers to patient care and serving as a pre-screening tool for studies. Advanced molecular testing is key to obtaining a precise diagnosis, discovering potentially actionable targets, and guiding management.","journal":"Journal of Neuro-Oncology","year":2024,"id":442011,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1255930,"name":"Thomas C. Wall","orcid":null,"position":1,"is_corresponding":false},{"id":1136427,"name":"Alvina Acquaye-Mallory","orcid":null,"position":2,"is_corresponding":false},{"id":429516,"name":"Lisa Boris","orcid":null,"position":3,"is_corresponding":false},{"id":367577,"name":"Yeonju Kim","orcid":"0000-0001-9220-4315","position":4,"is_corresponding":false},{"id":13200,"name":"Kenneth Aldape","orcid":"0000-0001-5119-7550","position":5,"is_corresponding":false},{"id":474953,"name":"Martha Quezado","orcid":"0009-0004-0941-8662","position":6,"is_corresponding":false},{"id":439997,"name":"John A. Butman","orcid":"0000-0002-1547-9195","position":7,"is_corresponding":false},{"id":415856,"name":"James G. Smirniotopoulos","orcid":"0000-0001-8422-7525","position":8,"is_corresponding":false},{"id":1255517,"name":"Huma Chaudhry","orcid":"0000-0002-3324-228X","position":9,"is_corresponding":false},{"id":439522,"name":"Christina Tsien","orcid":"0000-0002-5458-5732","position":10,"is_corresponding":false},{"id":356394,"name":"Prashant Chittiboina","orcid":"0000-0001-9349-4756","position":11,"is_corresponding":false},{"id":265853,"name":"Kareem A. Zaghloul","orcid":"0000-0001-8575-3578","position":12,"is_corresponding":false},{"id":422294,"name":"Orwa Aboud","orcid":"0000-0002-7916-1629","position":13,"is_corresponding":false},{"id":457856,"name":"Nicholas G. Avgeropoulos","orcid":null,"position":14,"is_corresponding":false},{"id":581419,"name":"Eric Burton","orcid":"0000-0002-4071-1574","position":15,"is_corresponding":false},{"id":426351,"name":"David Cachia","orcid":"0000-0002-5860-8452","position":16,"is_corresponding":false},{"id":275830,"name":"Karan Dixit","orcid":"0000-0003-0403-6054","position":17,"is_corresponding":false},{"id":364123,"name":"Jan Drappatz","orcid":"0000-0001-8187-7119","position":18,"is_corresponding":false},{"id":714703,"name":"Erin Dunbar","orcid":null,"position":19,"is_corresponding":false},{"id":225601,"name":"Peter Forsyth","orcid":"0000-0002-3756-8594","position":20,"is_corresponding":false},{"id":959637,"name":"Edina Komlódi-Pásztor","orcid":"0000-0002-4749-607X","position":21,"is_corresponding":false},{"id":1100654,"name":"Jacob Mandel","orcid":"0000-0001-5916-5668","position":22,"is_corresponding":false},{"id":960097,"name":"Byram H. Ozer","orcid":null,"position":23,"is_corresponding":false},{"id":428967,"name":"Eudocia Q. Lee","orcid":"0000-0003-3355-5179","position":24,"is_corresponding":false},{"id":1127797,"name":"Surabhi Ranjan","orcid":"0000-0001-7674-870X","position":25,"is_corresponding":false},{"id":242017,"name":"Rimas V. Lukas","orcid":"0000-0002-9352-5396","position":26,"is_corresponding":false},{"id":439999,"name":"Margarita Raygada","orcid":"0009-0009-6590-7926","position":27,"is_corresponding":false},{"id":787586,"name":"Michael Salacz","orcid":null,"position":28,"is_corresponding":false},{"id":721829,"name":"Matthew Smith-Cohn","orcid":"0000-0002-9102-0802","position":29,"is_corresponding":false},{"id":462106,"name":"James M. Snyder","orcid":"0000-0002-1386-2844","position":30,"is_corresponding":false},{"id":360802,"name":"Ariane Soldatos","orcid":"0000-0003-3570-5230","position":31,"is_corresponding":false},{"id":398851,"name":"Brett Theeler","orcid":null,"position":32,"is_corresponding":false},{"id":109206,"name":"Brigitte C. Widemann","orcid":"0000-0002-9198-7175","position":33,"is_corresponding":false},{"id":254789,"name":"Kevin Camphausen","orcid":"0000-0002-0450-4877","position":34,"is_corresponding":false},{"id":331838,"name":"John D. Heiss","orcid":"0000-0002-3890-0165","position":35,"is_corresponding":false},{"id":292546,"name":"Terri S. Armstrong","orcid":"0000-0002-2414-0492","position":36,"is_corresponding":false},{"id":109755,"name":"Mark R. Gilbert","orcid":"0000-0003-2556-9722","position":37,"is_corresponding":false},{"id":423237,"name":"Marta Peñas-Prado","orcid":null,"position":38,"is_corresponding":false},{"id":788796,"name":"James L. Rogers","orcid":"0000-0002-4790-5152","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:01:15.932178Z","pmid":"38427131","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}