{"doi":"10.1007/s11060-024-04569-7","title":"CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization","abstract":null,"journal":"Journal of Neuro-Oncology","year":2024,"id":635474,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648693,"name":"Sridhar Epari","orcid":null,"position":1,"is_corresponding":false},{"id":1648694,"name":"Omshree Shetty","orcid":null,"position":2,"is_corresponding":false},{"id":1648695,"name":"Sandeep Dhanavade","orcid":null,"position":3,"is_corresponding":false},{"id":1648696,"name":"Sheetal Chavan","orcid":null,"position":4,"is_corresponding":false},{"id":1648697,"name":"Ayushi Sahay","orcid":null,"position":5,"is_corresponding":false},{"id":1648699,"name":"Arpita Sahu","orcid":null,"position":6,"is_corresponding":false},{"id":1648701,"name":"Prakash Shetty","orcid":null,"position":7,"is_corresponding":false},{"id":1648703,"name":"Aliasgar Moiyadi","orcid":null,"position":8,"is_corresponding":false},{"id":1056189,"name":"Vikash Singh","orcid":"0000-0002-5325-1386","position":9,"is_corresponding":false},{"id":1648708,"name":"Archya Dasgupta","orcid":null,"position":10,"is_corresponding":false},{"id":117143,"name":"Abhishek Chatterjee","orcid":"0000-0002-6231-5302","position":11,"is_corresponding":false},{"id":1648711,"name":"Sadhana Kannan","orcid":null,"position":12,"is_corresponding":false},{"id":1648713,"name":"Tejpal Gupta","orcid":null,"position":13,"is_corresponding":false},{"id":1648692,"name":"Manali Ranade","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization","abstract":"<h4>Introduction</h4>CDKN2A/B homozygous deletion is one of the defining features of grade 4 in IDH-mutant astrocytic tumours.<h4>Aim</h4>To evaluate CDKN2A/B-deletion in IDH-mutant astrocytic tumours and its clinicopathological impact.<h4>Materials and methods</h4>CDKN2A/B-deletion was evaluated by Fluorescence in-situ hybridisation (FISH) and interpreted by two recently accepted methods.<h4>Results</h4>Eighty-three out of 94 cases (histologically-grade 2: 3, grade 3: 46, grade 4: 34) were interpretable on FISH. Concordant CDKN2A/B-deletion was observed in 71% (27/38) of lower-grade tumours (n = 49) and 90% (27/30) of histological grade 4 tumours (n = 34). Both the interpretation methods showed good agreement (Kappa = 0.75). CDKN2A/B-deletion showed an inverse correlation for < 10% MIB-1 labeling index (p = 0.01) while that by method-2 showed a significant correlation for grade 4 (p = 0.02). No significant correlation was observed for any other clinicopathological parameters. Twenty-four patients showed progression/recurrence (including deaths), and no significant difference in frequency of CDKN2A/B deletion was observed among cases with disease progression across different histological grades.<h4>Conclusions</h4>CDKN2A/B-deletion was observed across all the histological grades of IDH-mutant astrocytic tumours, expectedly more in the higher grade. FISH, as a method, can be used for the detection of CDKN2A/B homozygous deletion, when there is concordant interpretation.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38265748","pmcid":"PMC13287209","openalex_id":"https://openalex.org/W4391173811","authors":[],"funders":[],"total_grants":0,"fwci":1.4322,"citation_percentile":0.79973801,"influential_citations":0,"citation_trend":[{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13287209/","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13287209/","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.1007/s11060-024-04569-7.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s11060-024-04569-7","host_type":"publisher"},{"url":"https://doi.org/10.1007/s11060-024-04569-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38265748","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13287209","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13287209?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Glioma Diagnosis and Treatment","Epilepsy research and treatment","Tuberous Sclerosis Complex Research"],"mesh_terms":["Astrocytoma","Brain Neoplasms","Fluorescence","Homozygote","Humans","Isocitrate Dehydrogenase","Mutation","Sequence Deletion","Cyclin-Dependent Kinase Inhibitor p16","Cyclin-Dependent Kinase Inhibitor p15"],"keywords":["CDKN2A","Fluorescence in situ hybridization","Biology","In situ hybridization","Mutant","Correlation","Pathology","Molecular biology","Fish <Actinopterygii>","Medicine","Genetics","Gene","Gene expression","Astrocytoma","Cdkn2a/b","Fluorescence In-situ Hybridisation (Fish)","Idh-mutant"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:09:51.640731Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}