{"doi":"10.1007/s10803-020-04710-1","title":"Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis","abstract":"<jats:title>Abstract</jats:title><jats:p>The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41–1.53; <jats:italic>p</jats:italic> &lt; 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.</jats:p>","journal":"Journal of Autism and Developmental Disorders","year":2021,"id":596104,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":655527,"name":"Peng Zheng","orcid":"0000-0001-5907-8505","position":1,"is_corresponding":false},{"id":243292,"name":"Xiaobing Zou","orcid":"0000-0002-7380-0979","position":2,"is_corresponding":false},{"id":513880,"name":"Zhen Zheng","orcid":"0000-0002-6791-323X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis","abstract":"<jats:title>Abstract</jats:title><jats:p>The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41–1.53; <jats:italic>p</jats:italic> &lt; 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.</jats:p>","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33006697","pmcid":"PMC8254719","openalex_id":"https://openalex.org/W3090321217","authors":[],"funders":[{"funder_name":"National Science Foundation of China","grant_id":"81901523","title":null},{"funder_name":"National Science Foundation of China","grant_id":"81873801","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"19ykpy38","title":null}],"total_grants":3,"fwci":0.9611,"citation_percentile":0.74365482,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":4},{"year":2023,"count":7},{"year":2024,"count":5},{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s10803-020-04710-1.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s10803-020-04710-1.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10803-020-04710-1/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10803-020-04710-1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33006697","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8254719","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8254719","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8254719?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["S100 Proteins and Annexins","Autism Spectrum Disorder Research","Antimicrobial Peptides and Activities","Adolescent","Autism Spectrum Disorder","Biomarkers","Child","Child, Preschool","Female","Humans","Male","S100 Calcium Binding Protein beta Subunit"],"mesh_terms":["Autism Spectrum Disorder","Adolescent","Child","Child, Preschool","Female","Humans","Male","Biomarkers","S100 Calcium Binding Protein beta Subunit"],"keywords":["Meta-analysis","Strictly standardized mean difference","Biomarker","Peripheral blood","Autism","Confidence interval","Peripheral","Autism spectrum disorder","Psychology","Internal medicine","Systematic review","Medicine","MEDLINE","Psychiatry","Biology","Blood","S100B"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T23:51:56.412316Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}