{"doi":"10.1007/s10637-021-01079-5","title":"Histone deacetylase inhibitor chidamide regulates the Wnt/β-catenin pathway by MYCN/DKK3 in B-ALL","abstract":null,"journal":"Investigational New Drugs","year":2021,"id":612818,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1578100,"name":"Chengfang Lv","orcid":null,"position":1,"is_corresponding":false},{"id":127240,"name":"Lili Sun","orcid":null,"position":2,"is_corresponding":false},{"id":933805,"name":"Qi Li","orcid":"0000-0001-5699-9843","position":3,"is_corresponding":false},{"id":1578101,"name":"Yuhuang Wang","orcid":null,"position":4,"is_corresponding":false},{"id":257445,"name":"Min Wu","orcid":"0000-0003-1205-982X","position":5,"is_corresponding":false},{"id":557224,"name":"Yuying Wang","orcid":"0000-0002-3419-6967","position":6,"is_corresponding":false},{"id":1578103,"name":"Zhibo Guo","orcid":null,"position":7,"is_corresponding":false},{"id":1578104,"name":"Sicheng Bian","orcid":null,"position":8,"is_corresponding":false},{"id":1578105,"name":"Desheng Kong","orcid":null,"position":9,"is_corresponding":false},{"id":1578106,"name":"Leilei Lin","orcid":null,"position":10,"is_corresponding":false},{"id":1204114,"name":"Yu Wang","orcid":"0000-0002-8683-6196","position":11,"is_corresponding":false},{"id":683340,"name":"Jin Zhou","orcid":"0000-0001-8121-4198","position":12,"is_corresponding":false},{"id":673845,"name":"Yinghua Li","orcid":"0000-0002-2391-6738","position":13,"is_corresponding":false},{"id":168692,"name":"Linlin Zhao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Histone deacetylase inhibitor chidamide regulates the Wnt/β-catenin pathway by MYCN/DKK3 in B-ALL","abstract":"Our previous studies revealed that MYCN downregulates the expression of DKK3, activates the Wnt/β-catenin signalling pathway at the transcriptional level, and thereby promotes the development of B cell acute lymphocytic leukaemia (B-ALL) but does not affect the methylation of the DKK3 promoter. Some studies have shown that MYCN is associated with histone acetylation. We speculate that histone deacetylase inhibitors (HDACis) can inhibit the Wnt/β-catenin signalling pathway by inhibiting MYCN and increasing the expression of DKK3. Based on previous experiments, we tested this hypothesis by analysing the changes in MYCN, DKK3 and the Wnt/β-catenin signalling pathways in B-ALL cells after treatment with the selective HDACi chidamide. The in vitro and in vivo experiments confirmed that chidamide inhibited the expression of MYCN and increased the expression of DKK3 by inhibiting the activity of histone deacetylase, and these effects resulted in inhibition of the Wnt/β-catenin signalling pathway and the proliferation of B-ALL cells. These findings indicate that chidamide might be used alone or in combination with other chemotherapy regimens for patients with B-ALL and thus provide a new approach to the treatment of B-ALL.","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33566253","pmcid":null,"openalex_id":"https://openalex.org/W3126958487","authors":[],"funders":[{"funder_name":"Scientific Research and Innovation Fund of the First affiliated Hospital of Harbin Medical University","grant_id":"2020B15","title":null},{"funder_name":"Foundation for the Dean of Southern University of Science and Technology Hospital in 2020","grant_id":"2020-A3","title":null}],"total_grants":2,"fwci":7.0322,"citation_percentile":0.9751827,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":32},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s10637-021-01079-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10637-021-01079-5/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10637-021-01079-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33566253","host_type":"repository"}],"fields_of_study":["Acute Lymphoblastic Leukemia research","Childhood Cancer Survivors' Quality of Life","Histone Deacetylase Inhibitors Research","Adaptor Proteins, Signal Transducing","Aminopyridines","Animals","Benzamides","Cell Line, Tumor","Cell Proliferation","Gene Expression Regulation, Neoplastic","Histone Deacetylase Inhibitors","Humans","Mice","Mice, Inbred NOD","Mice, SCID","N-Myc Proto-Oncogene Protein","Precursor Cell Lymphoblastic Leukemia-Lymphoma","Wnt Signaling Pathway","Xenograft Model Antitumor Assays"],"mesh_terms":["N-Myc Proto-Oncogene Protein","Aminopyridines","Animals","Benzamides","Humans","Gene Expression Regulation, Neoplastic","Mice, SCID","Mice, Inbred NOD","Xenograft Model Antitumor Assays","Cell Line, Tumor","Adaptor Proteins, Signal Transducing","Cell Proliferation","Mice","Precursor Cell Lymphoblastic Leukemia-Lymphoma","Histone Deacetylase Inhibitors","Wnt Signaling Pathway"],"keywords":["Wnt signaling pathway","Histone deacetylase","Histone deacetylase inhibitor","Acetylation","Cancer research","Catenin","Biology","HDAC1","Histone","Cell growth","Histone deacetylase 2","Signal transduction","Cell biology","Biochemistry","Gene","Mycn","Dkk3","Wnt/β-catenin","Chidamide","B Cell Acute Lymphocytic Leukaemia"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T05:05:38.484235Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}